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serine protease 8

Summary

Gene Symbol

Prss8

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

192107

PubChem

192107

Alliance of Genome Resources

RGD:619973

Annotation

Keyword

Cell membrane
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Transmembrane helix
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ES87	Channel-activating protease 1 Serine protease 8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
hair follicle development	ISO
proteolysis	IEA
response to xenobiotic stimulus	IEP	12506133
positive regulation of sodium ion transport	ISO
positive regulation of sodium ion transport	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure development [inference]

hair follicle development

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

response to chemical [inference]

response to xenobiotic stimulus

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to mineralocorticoid

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to peptide [inference]

response to peptide hormone

localization [inference]

establishment of localization [inference]

transport [inference]

transepithelial transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of sodium ion transport [inference]

positive regulation of sodium ion transport

positive regulation of sodium ion transmembrane transport

regulation of sodium ion transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of sodium ion transmembrane transport

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of sodium ion transmembrane transport

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of monoatomic ion transport [inference]

positive regulation of sodium ion transport

positive regulation of sodium ion transmembrane transport

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

regulation of monoatomic cation transmembrane transport [inference]

regulation of sodium ion transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of sodium ion transmembrane transport

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	IDA	12506133
plasma membrane	ISO
plasma membrane	IEA
external side of plasma membrane	ISO
membrane raft	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

membrane microdomain [inference]

membrane raft

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IEA
sodium channel regulator activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

molecular function regulator activity [inference]

transporter regulator activity [inference]

channel regulator activity [inference]

ion channel regulator activity [inference]

sodium channel regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serine protease

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 6** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Serine proteases, trypsin family, serine active site

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:12506133

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:987	alopecia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 51 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	5652	Xenbase:XB-GENE-5758112	HUMAN27983
Danio rerio	25823	ZFIN:ZDB-GENE-040718-339
Danio rerio	30943	ZFIN:ZDB-GENE-040718-339
Danio rerio	70835	ZFIN:ZDB-GENE-040718-339
Mus musculus	76560	Xenbase:XB-GENE-5758112	MOUSE53523
Xenopus tropicalis	192107	Xenbase:XB-GENE-5758112
Danio rerio	287106	ZFIN:ZDB-GENE-040718-339
Pan troglodytes	454065		PANTR12218
Bos taurus	613506		BOVIN20647
Macaca mulatta	713176		MACMU27246