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pre-mRNA processing factor 8

Summary

Gene Symbol

Prpf8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

192159

PubChem

192159

Alliance of Genome Resources

MGI:2179381

Annotation

Keyword

Acetylation
Methylation
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Ribonucleoprotein
Spliceosome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UNG1
Q99PV0	Splicing factor Prp8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
spliceosomal tri-snRNP complex assembly	ISS
spliceosomal tri-snRNP complex assembly	ISO
spliceosomal tri-snRNP complex assembly	IBA
mRNA splicing, via spliceosome	ISS
mRNA splicing, via spliceosome	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal snRNP assembly [inference]

spliceosomal tri-snRNP complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

spliceosomal snRNP assembly [inference]

spliceosomal tri-snRNP complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

spliceosomal snRNP assembly [inference]

spliceosomal tri-snRNP complex assembly

response to stimulus [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to chemical [inference]

response to organic substance [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

response to lipid [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to lipid [inference]

cellular response to lipopolysaccharide

response to cytokine [inference]

response to tumor necrosis factor [inference]

cellular response to tumor necrosis factor

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

response to oxygen-containing compound [inference]

response to lipopolysaccharide [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to tumor necrosis factor

cellular response to lipid [inference]

cellular response to lipopolysaccharide

cellular response to oxygen-containing compound [inference]

cellular response to lipopolysaccharide

cellular response to biotic stimulus [inference]

cellular response to molecule of bacterial origin [inference]

cellular response to lipopolysaccharide

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	ISO
U5 snRNP	ISO
U5 snRNP	IBA
nuclear speck	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

Sm-like protein family complex [inference]

small nuclear ribonucleoprotein complex

spliceosomal snRNP complex [inference]

U5 snRNP

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

nuclear protein-containing complex [inference]

spliceosomal complex [inference]

U2-type spliceosomal complex [inference]

precatalytic spliceosome [inference]

U2-type precatalytic spliceosome

catalytic step 1 spliceosome [inference]

U2-type catalytic step 1 spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

small nuclear ribonucleoprotein complex

spliceosomal snRNP complex [inference]

U5 snRNP

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

catalytic complex [inference]

catalytic step 1 spliceosome [inference]

U2-type catalytic step 1 spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

ribonucleoprotein complex [inference]

spliceosomal complex [inference]

U2-type spliceosomal complex [inference]

precatalytic spliceosome [inference]

U2-type precatalytic spliceosome

catalytic step 1 spliceosome [inference]

U2-type catalytic step 1 spliceosome

catalytic step 2 spliceosome

U2-type catalytic step 2 spliceosome

small nuclear ribonucleoprotein complex

spliceosomal snRNP complex [inference]

U5 snRNP

spliceosomal tri-snRNP complex [inference]

U4/U6 x U5 tri-snRNP complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
metallopeptidase activity	IEA
U6 snRNA binding	IBA
U6 snRNA binding	IEA
U1 snRNA binding	IBA
U2 snRNA binding	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

metallopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

metallopeptidase activity

binding [inference]

protein binding [inference]

modification-dependent protein binding [inference]

polyubiquitin modification-dependent protein binding [inference]

K63-linked polyubiquitin modification-dependent protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

snRNA binding [inference]

pre-mRNA binding [inference]

pre-mRNA intronic binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

pre-mRNA-processing-splicing factor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
U1 snRNA binding
U2 snRNA binding
U5 snRNA binding
U6 snRNA binding
mRNA processing
metallopeptidase activity
pre-mRNA intronic binding

Displaying entries **1 - 10** of 14 in total

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InterPro
JAB1/MPN/MOV34 metalloenzyme domain
MPN domain
PRO8NT domain
PROCN domain
PROCT domain
PRP8 domain IV core
Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily
Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding
Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding
Pre-mRNA-processing-splicing factor 8

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0110403	retinitis pigmentosa 13	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 84 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	10594	Xenbase:XB-GENE-966799	HUMAN30674
Xenopus tropicalis	192159	Xenbase:XB-GENE-966799
Rattus norvegicus	287530		RATNO00445
Danio rerio	393951		DANRE08527
Pan troglodytes	468374		PANTR13191
Canis lupus familiaris	480651		CANLF19149
Bos taurus	507371		BOVIN12500
Macaca mulatta	721238		MACMU14570
Monodelphis domestica	100012573		MONDO15900
Equus caballus	100072388		HORSE02951

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OrthoDB (Group)

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Acknowledgements