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heat shock protein family B (small) member 6

Summary

Gene Symbol

Hspb6

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

192245

PubChem

192245

Alliance of Genome Resources

RGD:621554

Annotation

Keyword

3D-structure
Chaperone
Cytoplasm
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Secreted
Stress response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6J9Y5
P97541	Heat shock 20 kDa-like protein p20

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
negative regulation of cardiac muscle cell apoptotic process	IDA	15105294

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

response to stimulus [inference]

response to stress [inference]

response to heat

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nuclear speck	IEA ISO
extracellular region	IEA ISO
mitochondrion	IEA ISO
nucleus	IBA ISO ISS
cytosol	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

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GO Term	Evidence Code	PMID
protein-folding chaperone binding	IEA ISO
structural constituent of eye lens	IEA
protein kinase binding	IPI	25889640
protein folding chaperone	IEA ISO
protein homodimerization activity	IPI	19646995

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of eye lens

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

heat shock protein beta-6

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
protein refolding
structural constituent of eye lens
unfolded protein binding

Displaying **all 4** entries
InterPro
Alpha crystallin/Hsp20 domain
Alpha crystallin/Small heat shock protein, animal type
Alpha-crystallin, N-terminal
HSP20-like chaperone

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080093	myofibrillar myopathy 2	Alliance of Genome Resources

Ortholog

Displaying entries **31 - 40** of 87 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Microtus ochrogaster	101979415	79684_0:003384
Chinchilla lanigera	102022805	34839_0:003265		CHILA16476
Capra hircus	102172571			CAPHI08866
Pelodiscus sinensis	102447067			PELSI01737
Peromyscus maniculatus bairdii	102921045	230844_0:000698
Chlorocebus sabaeus	103234539			CHLSB15646
Nannospalax galili	103729937	1026970_0:000b78		NANGA23188
Rhinopithecus roxellana	104667080			RHIRO32005
Fukomys damarensis	104867490	885580_0:0027c9
Pteropus vampyrus	105306653			PTEVA13232

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024