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heat shock protein family B (small) member 6

Summary

Gene Symbol

Hspb6

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

192245

PubChem

192245

Alliance of Genome Resources

RGD:621554

Annotation

Keyword

3D-structure
Chaperone
Cytoplasm
Direct protein sequencing
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Secreted
Stress response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6J9Y5
P97541	Heat shock 20 kDa-like protein p20

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chaperone-mediated protein folding	IEA ISO
positive regulation of angiogenesis	IEA ISO
protein refolding	IBA
negative regulation of apoptotic process	IBA
response to heat	IBA

GO Hierarchy

biological process

cellular process [inference]

protein folding [inference]

response to stimulus [inference]

response to stress [inference]

response to heat

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of muscle cell apoptotic process [inference]

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of striated muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of cardiac muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of muscle cell apoptotic process [inference]

negative regulation of striated muscle cell apoptotic process [inference]

negative regulation of cardiac muscle cell apoptotic process

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA ISO ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein-folding chaperone binding	IEA ISO
structural constituent of eye lens	IEA
protein kinase binding	IPI	25889640
protein folding chaperone	IEA ISO
protein homodimerization activity	IPI	19646995

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of eye lens

binding [inference]

protein binding [inference]

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

protein folding chaperone

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

heat shock protein beta-6

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
Gene Ontology
protein refolding
structural constituent of eye lens
unfolded protein binding

Displaying **all 4** entries
InterPro
Alpha crystallin/Hsp20 domain
Alpha crystallin/Small heat shock protein, animal type
Alpha-crystallin, N-terminal
HSP20-like chaperone

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080093	myofibrillar myopathy 2	Alliance of Genome Resources

Ortholog

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Arvicola amphibius	119821169	1047088_0:0032f1
Microtus oregoni	121450074	111838_0:0014f3
Dipodomys spectabilis	122097514	105255_0:0045b7
Panthera leo	122208253		PANLE30028
Ursus americanus	123793897		URSAM00262
Marmota monax	124095013	9995_0:001368
Sciurus carolinensis	124966419	30640_0:00458f
Perognathus longimembris pacificus	125368015	214514_0:0040b6
Myodes glareolus	125403137	447135_0:00020f
Microtus fortis	126486773	100897_0:003b47

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Annotation

OrthoDB (Group)

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Acknowledgements