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Annotation

Keyword

Cell membrane
Coiled coil
Direct protein sequencing
Glycoprotein
Hydrolase
Phospholipid metabolism
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O54728	Lysophospholipase Phospholipase A2 Phospholipase B/lipase Triacylglycerol lipase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
lipid metabolic process	IEA
phospholipid metabolic process	IDA	1716922
phospholipid metabolic process	IBA
triglyceride catabolic process	IDA	9442064 9442065
phosphatidylglycerol catabolic process	IDA	9442064

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

acylglycerol catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

acylglycerol catabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

acylglycerol catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

acylglycerol catabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic substance metabolic process [inference]

lipid metabolic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

acylglycerol catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

acylglycerol catabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

olefinic compound metabolic process [inference]

retinol metabolic process

organonitrogen compound metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid metabolic process [inference]

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

acylglycerol catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

neutral lipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

triglyceride metabolic process [inference]

triglyceride catabolic process

diacylglycerol metabolic process [inference]

diacylglycerol catabolic process

acylglycerol catabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process [inference]

phosphatidylglycerol catabolic process

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

acylglycerol catabolic process [inference]

glycerophospholipid catabolic process [inference]

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

regulation of reproductive process [inference]

regulation of acrosome reaction [inference]

positive regulation of acrosome reaction

positive regulation of reproductive process [inference]

positive regulation of acrosome reaction

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
apical plasma membrane	IEA
brush border membrane	IDA	1716922 8117729
brush border membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane region [inference]

apical plasma membrane

cell projection membrane [inference]

brush border membrane

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
phospholipase activity	IEA
lysophospholipase activity	IDA	1716922 9442064 9442065
lysophospholipase activity	IBA
lysophospholipase activity	IEA
phospholipase A2 activity	IDA	1716922

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity

lysophospholipase activity

phospholipase A2 activity

calcium-independent phospholipase A2 activity

triglyceride lipase activity

carboxylic ester hydrolase activity [inference]

lysophospholipase activity

phospholipase A2 activity

calcium-independent phospholipase A2 activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phospholipase

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
hydrolase activity, acting on ester bonds
phospholipase activity
phospholipid metabolic process
retinyl-palmitate esterase activity

Displaying **all 3** entries
InterPro
GDSL lipase/esterase
Phospholipase B1, membrane-associated
SGNH hydrolase superfamily

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
brush border membrane	PMID:1716922 PMID:8117729

Rhea

RHEA:15177

H₂O + a 1-acyl-sn-glycero-3-phosphocholine

H⁺ + sn-glycerol 3-phosphocholine + a fatty acid

Enzyme

3.1.1.5

PMID

RHEA:36231

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + 1-O-alkyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

9442064

RHEA:12044

H₂O + a triacylglycerol

H⁺ + a diacylglycerol + a fatty acid

Enzyme

PMID

RHEA:15801

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 1-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP012960
Gene Name: phospholipase B1

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	151056	Xenbase:XB-GENE-997742	HUMAN62073
Xenopus tropicalis	174746	Xenbase:XB-GENE-997742
Xenopus tropicalis	181691	Xenbase:XB-GENE-997742
Xenopus tropicalis	192259	Xenbase:XB-GENE-997742
Pan troglodytes	459117		PANTR27323
Canis lupus familiaris	611194		CANLF05005
Mus musculus	665270	Xenbase:XB-GENE-997742	MOUSE46532
Monodelphis domestica	768082		MONDO07439
Oryctolagus cuniculus	100009309		RABIT08754
Equus caballus	100071076		HORSE09645

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements