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nitric oxide synthase 1 adaptor protein

Summary

Gene Symbol

Nos1ap

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

192363

PubChem

192363

Alliance of Genome Resources

RGD:620106

Annotation

Keyword

Cell junction
Cell projection
Coiled coil
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O54960	C-terminal PDZ ligand of neuronal nitric oxide synthase protein Nitric oxide synthase 1 adaptor protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IDA	24665357
regulation of nitric oxide biosynthetic process	TAS	20431962
positive regulation of peptidyl-cysteine S-nitrosylation	IMP	24665357
regulation of high voltage-gated calcium channel activity	IDA	24665357
regulation of heart rate by chemical signal	ISO

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

developmental process [inference]

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

neuron projection regeneration

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration

localization [inference]

establishment of localization [inference]

transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell [inference]

neurotransmitter secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nitric oxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of peptidyl-cysteine S-nitrosylation [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of calcium ion transmembrane transporter activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of cation channel activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

regulation of cation channel activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

regulation of cation channel activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of peptidyl-cysteine S-nitrosylation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nitric oxide biosynthetic process

regulation of transmembrane transport [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of calcium ion transmembrane transporter activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of cation channel activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium ion transmembrane transporter activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

regulation of cation channel activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of heart rate [inference]

regulation of heart rate by chemical signal

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization

regulation of action potential [inference]

regulation of cardiac muscle cell action potential

regulation of biological quality [inference]

regulation of heart rate [inference]

regulation of heart rate by chemical signal

regulation of membrane potential [inference]

regulation of membrane repolarization [inference]

regulation of cardiac muscle cell membrane repolarization [inference]

regulation of ventricular cardiac muscle cell membrane repolarization

regulation of action potential [inference]

regulation of cardiac muscle cell action potential

regulation of molecular function [inference]

regulation of transporter activity [inference]

regulation of transmembrane transporter activity [inference]

regulation of monoatomic ion transmembrane transporter activity [inference]

regulation of calcium ion transmembrane transporter activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of cation channel activity [inference]

regulation of voltage-gated calcium channel activity [inference]

regulation of high voltage-gated calcium channel activity

regulation of catalytic activity [inference]

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

regulation of nitric-oxide synthase activity

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
sarcoplasmic reticulum membrane	ISO
nuclear membrane	IDA	24665357
anchoring junction	IEA
postsynapse	IDA IMP	20357130
presynapse	IDA IMP	20357130

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

nuclear membrane

bounding membrane of organelle [inference]

sarcoplasmic reticulum membrane

plasma membrane region [inference]

plasma membrane raft [inference]

caveola

membrane microdomain [inference]

membrane raft [inference]

plasma membrane raft [inference]

caveola

Z disc

cell junction [inference]

synapse [inference]

glutamatergic synapse

anchoring junction

T-tubule

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

filopodium

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

podosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	11086993 11867766
mitogen-activated protein kinase kinase binding	IPI	23658158
protease binding	IPI	19553464
PDZ domain binding	IDA	9459447
signaling adaptor activity	IDA	9459447

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

protease binding

kinase binding [inference]

protein kinase binding [inference]

mitogen-activated protein kinase kinase binding

nitric-oxide synthase binding

protein domain specific binding [inference]

PDZ domain binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
nitric-oxide synthase binding

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0112268	nephrotic syndrome type 22	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:11723	Duchenne muscular dystrophy	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:6000	congestive heart failure	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 46 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources
Homo sapiens	9722		HGNC:16859
Drosophila melanogaster	39111		FB:FBgn0261555
Mus musculus	70729	10090_1:000443	MGI:1917979
Danio rerio	553539		ZFIN:ZDB-GENE-081024-1
Xenopus tropicalis	780172		Xenbase:XB-GENE-5751148
Cavia porcellus	100730617	10141_0:00197e
Cricetulus griseus	100771018	10029_0:0036d5
Octodon degus	101582628	10160_0:00346b
Jaculus jaculus	101601843	51337_0:000879
Heterocephalus glaber	101707923	10181_0:003a95

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements