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phospholipase A2, group XV

Summary

Gene Symbol

Pla2g15

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

192654

PubChem

192654

Alliance of Genome Resources

MGI:2178076

Annotation

Keyword

Acyltransferase
Disulfide bond
Fatty acid metabolism
Glycoprotein
Hydrolase
Lysosome
Membrane
Metal-binding
Reference proteome
Secreted
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8VEB4	1-O-acylceramide synthase LCAT-like lysophospholipase Lysophospholipase 3 Lysosomal phospholipase A2 Phospholipase A2 group XV

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
ceramide metabolic process	IBA IDA ISO	11790796 16837646 20410020
phosphatidylethanolamine catabolic process	IDA IMP	16837646 16880524
phosphatidylcholine metabolic process	IBA ISO
phosphatidylcholine catabolic process	IDA IMP	16837646 16880524 17626977
fatty acid metabolic process	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

ceramide metabolic process

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organonitrogen compound metabolic process [inference]

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process

sphingolipid metabolic process [inference]

ceramide metabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organonitrogen compound catabolic process [inference]

phosphatidylcholine catabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

cellular modified amino acid metabolic process [inference]

phosphatidylserine metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

organophosphate catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

neutral lipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

neutral lipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

glycerolipid metabolic process [inference]

acylglycerol metabolic process [inference]

diacylglycerol metabolic process [inference]

diacylglycerol biosynthetic process

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerophospholipid metabolic process

phosphatidylserine metabolic process

phosphatidylethanolamine metabolic process [inference]

phosphatidylethanolamine catabolic process

phosphatidylcholine metabolic process

phosphatidylcholine catabolic process

phosphatidylglycerol metabolic process

glycerophospholipid catabolic process [inference]

glycerolipid biosynthetic process [inference]

acylglycerol biosynthetic process [inference]

diacylglycerol biosynthetic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
membrane	IEA
intracellular membrane-bounded organelle	ISO
nucleoplasm	IEA ISO
mitochondrion	HDA	18614015
lysosome	IBA IDA ISS	29514215

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

mitochondrion

vacuole [inference]

lytic vacuole [inference]

lysosome

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GO Term	Evidence Code	PMID
zinc ion binding	ISO ISS
O-acyltransferase activity	IBA IDA ISO ISS	16837646 20410020
phospholipase A1 activity	IDA IEA ISO	16837646
acylglycerol O-acyltransferase activity	IDA	17626977
1-acyl-2-lysophosphatidylserine acylhydrolase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity

acylglycerol O-acyltransferase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

lysophospholipase activity

phospholipase A2 activity [inference]

calcium-independent phospholipase A2 activity

carboxylic ester hydrolase activity [inference]

lysophospholipase activity

phospholipase A2 activity [inference]

calcium-independent phospholipase A2 activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

group XV phospholipase A2

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 6** entries
Gene Ontology
O-acyltransferase activity
calcium-independent phospholipase A2 activity
ceramide metabolic process
hydrolase activity
lipid metabolic process
phosphatidylcholine metabolic process

Displaying **all 2** entries
InterPro
Alpha/Beta hydrolase fold
Lecithin

Rhea

RHEA:15801

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 1-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

RHEA:18689

H₂O + a 1,2-diacyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + a 2-acyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.32

PMID

RHEA:15177

H₂O + a 1-acyl-sn-glycero-3-phosphocholine

H⁺ + sn-glycerol 3-phosphocholine + a fatty acid

Enzyme

3.1.1.5

PMID

RHEA:36231

H₂O + 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine

H⁺ + a fatty acid + 1-O-alkyl-sn-glycero-3-phosphocholine

Enzyme

3.1.1.4

PMID

9442064

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002561
Gene Name: phospholipase A2, group XV

Ortholog

Displaying entries **1 - 10** of **115** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	23659		HGNC:17163	HUMAN29250
Caenorhabditis elegans	172457		WB:WBGene00010872
Drosophila melanogaster	261623		FB:FBgn0051683
Bos taurus	282271			BOVIN10673
Drosophila melanogaster	326109		FB:FBgn0042175
Danio rerio	335008		ZFIN:ZDB-GENE-030131-6948
Rattus norvegicus	361401	10116_1:00507d	RGD:1302982	RATNO14504
Canis lupus familiaris	403403			CANLF16022
Pan troglodytes	454188			PANTR12675
Macaca mulatta	702619			MACMU26106

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements