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Guidelines

MIRAGE

protein tyrosine phosphatase receptor type M

Summary

Gene Symbol

Ptprm

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19274

PubChem

19274

Alliance of Genome Resources

MGI:102694

Annotation

Keyword

Cell adhesion
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Protein phosphatase
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P28828
Q68FM4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 24** of 24 in total

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GO Term	Evidence Code	PMID
neuron projection development	IBA
retinal ganglion cell axon guidance	ISS
retinal ganglion cell axon guidance	ISO
vasodilation	IMP	15706045

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

macromolecule modification [inference]

protein modification process [inference]

protein dephosphorylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein dephosphorylation

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion [inference]

cell-cell adhesion via plasma-membrane adhesion molecules [inference]

homophilic cell adhesion via plasma membrane adhesion molecules

signal transduction

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation [inference]

protein dephosphorylation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

neuron projection guidance [inference]

axon guidance [inference]

retinal ganglion cell axon guidance

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasodilation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

retina layer formation

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of biological process [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of cellular process [inference]

signal transduction

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

regulation of epithelial cell proliferation [inference]

regulation of endothelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation [inference]

negative regulation of endothelial cell proliferation

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of cell motility [inference]

negative regulation of cell migration [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of multicellular organismal process [inference]

negative regulation of epithelial cell migration [inference]

negative regulation of endothelial cell migration

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasodilation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
plasma membrane	ISO
plasma membrane	IEA
cell-cell junction	ISO
adherens junction	ISS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

adherens junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein tyrosine phosphatase activity	ISO
protein tyrosine phosphatase activity	IBA
non-membrane spanning protein tyrosine phosphatase activity	IEA
transmembrane receptor protein tyrosine phosphatase activity	ISS
transmembrane receptor protein tyrosine phosphatase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

catalytic activity, acting on a protein [inference]

phosphoprotein phosphatase activity [inference]

protein tyrosine phosphatase activity

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

histone modifying activity [inference]

histone phosphatase activity [inference]

histone H2AXY142 phosphatase activity

binding [inference]

protein binding

identical protein binding

cell adhesion molecule binding [inference]

cadherin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

transmembrane receptor protein phosphatase activity [inference]

transmembrane receptor protein tyrosine phosphatase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor-type tyrosine-protein phosphatase T

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
dephosphorylation
protein tyrosine phosphatase activity

Displaying **all 5** entries
InterPro
Protein-tyrosine phosphatase, active site
Protein-tyrosine phosphatase, catalytic
Protein-tyrosine phosphatase-like
Tyrosine-specific protein phosphatase, PTPase domain
Tyrosine-specific protein phosphatases domain

Ortholog

Displaying entries **21 - 30** of **100** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Equus caballus	100059664		HORSE41499
Ornithorhynchus anatinus	100075776		ORNAN22843
Pongo abelii	100173948		PONAB13411
Taeniopygia guttata	100229800		TAEGU19216
Oryctolagus cuniculus	100356969		RABIT13058
Callithrix jacchus	100397924		CALJA09049
Ailuropoda melanoleuca	100465579		AILME14442
Nomascus leucogenys	100597968		NOMLE28216
Sus scrofa	100624854		PIGXX29770
Oreochromis niloticus	100690029		ORENI29689

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Last updated: December 8, 2025