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Guidelines

MIRAGE

integrin beta 4

Summary

Gene Symbol

Itgb4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

192897

PubChem

192897

Alliance of Genome Resources

MGI:96613

Annotation

Keyword

Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Integrin
Magnesium
Metal-binding
Palmitate
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A2A863
A2A864

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
autophagy	ISO
autophagy	IEA
cell adhesion	IMP	8707838
cell-matrix adhesion	ISO
cell-matrix adhesion	IBA

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular process [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

peripheral nervous system axon ensheathment [inference]

myelination in peripheral nervous system

myelination [inference]

myelination in peripheral nervous system

cellular metabolic process [inference]

cellular catabolic process [inference]

autophagy

cellular developmental process [inference]

cell differentiation [inference]

mesodermal cell differentiation

ameboidal-type cell migration [inference]

trophoblast cell migration

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly [inference]

peripheral nervous system myelin formation

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell junction assembly [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

cell projection organization [inference]

cell projection assembly [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

plasma membrane bounded cell projection organization [inference]

plasma membrane bounded cell projection assembly [inference]

filopodium assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

cell-substrate junction organization [inference]

cell-substrate junction assembly [inference]

hemidesmosome assembly

reproductive process [inference]

trophoblast cell migration

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

skin morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

myelin assembly [inference]

peripheral nervous system myelin formation

anatomical structure development [inference]

nail development

cellular developmental process [inference]

cell differentiation [inference]

mesodermal cell differentiation

response to stimulus [inference]

response to stress [inference]

response to wounding

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
basement membrane	IDA	17011173
nucleolus	ISO
nucleolus	IEA
plasma membrane	ISO
focal adhesion	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

receptor complex

plasma membrane signaling receptor complex [inference]

integrin complex

protein complex involved in cell adhesion [inference]

integrin complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex

cell surface

membrane [inference]

plasma membrane

organelle membrane [inference]

nuclear membrane

plasma membrane region [inference]

basal plasma membrane

synaptic membrane [inference]

postsynaptic membrane

synapse [inference]

glutamatergic synapse

anchoring junction [inference]

cell-substrate junction [inference]

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix [inference]

basement membrane

cell leading edge

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
G protein-coupled receptor binding	ISO
G protein-coupled receptor binding	IEA
integrin binding	IBA
protein binding	IPI	16436605 29315582
insulin-like growth factor I binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

growth factor binding [inference]

insulin-like growth factor binding [inference]

insulin-like growth factor I binding

neuregulin binding

cell adhesion molecule binding [inference]

integrin binding

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

integrin beta-4

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
cell adhesion mediated by integrin
cell communication
cell migration
cell-matrix adhesion
integrin binding
integrin-mediated signaling pathway

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InterPro
CalX-like domain superfamily
Fibronectin type III superfamily
Fibronectin type III
Immunoglobulin-like fold
Integrin beta N-terminal
Integrin beta subunit, VWA domain
Integrin beta subunit, tail
Integrin beta subunit
Integrin beta tail domain superfamily
Integrin beta, epidermal growth factor-like domain 1

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060733	junctional epidermolysis bullosa with pyloric atresia	Alliance of Genome Resources
DOID:0060738	junctional epidermolysis bullosa non-Herlitz type	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	3691	Xenbase:XB-GENE-1013662	HUMAN36311
Rattus norvegicus	25724	Xenbase:XB-GENE-1013662	RATNO01621
Xenopus tropicalis	35368	Xenbase:XB-GENE-1013662
Xenopus tropicalis	44885	Xenbase:XB-GENE-1013662
Xenopus tropicalis	175504	Xenbase:XB-GENE-1013662
Xenopus tropicalis	192897	Xenbase:XB-GENE-1013662
Danio rerio	335269		DANRE41976
Pan troglodytes	454887		PANTR15449
Bos taurus	506995		BOVIN13977
Macaca mulatta	703770		MACMU14038

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025