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MIRAGE

RAB4B, member RAS oncogene family

Summary

Gene Symbol

Rab4b

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

19342

PubChem

19342

Alliance of Genome Resources

MGI:105071

Annotation

Keyword

Acetylation
Cell membrane
Endosome
GTP-binding
Hydrolase
Membrane
Methylation
Phosphoprotein
Prenylation
Protein transport
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q91ZR1
Q4V9W8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
protein transport	IEA
vesicle-mediated transport	IBA
regulation of endocytosis	IBA
Rab protein signal transduction	IEA
endosomal vesicle fusion	ISO

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rab protein signal transduction

vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

Golgi vesicle transport [inference]

early endosome to Golgi transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport [inference]

glucose import

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

endosomal vesicle fusion

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

endosomal vesicle fusion

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

endosomal vesicle fusion

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

vesicle-mediated transport

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

Golgi vesicle transport [inference]

early endosome to Golgi transport

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport [inference]

glucose import

organic substance transport [inference]

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport [inference]

glucose import

protein transport

nitrogen compound transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cytosolic transport [inference]

retrograde transport, endosome to Golgi [inference]

early endosome to Golgi transport

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rab protein signal transduction

regulation of cellular component organization [inference]

regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
mitochondrion	HDA	18614015
cytosol	IEA
plasma membrane	IEA
synaptic vesicle membrane	ISO
early endosome membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

recycling endosome

secretory vesicle [inference]

secretory granule [inference]

insulin-responsive compartment

perinuclear region of cytoplasm

Displaying **all 5** entries
GO Term	Evidence Code	PMID
GTPase activity	ISO
GTPase activity	IBA
G protein activity	IEA
GTP binding	IBA
GTP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

GTPase activity

G protein activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

molecular function regulator activity [inference]

G protein activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

rab

Functional Category

T: Signal transduction mechanisms
U: Intracellular trafficking, secretion, and vesicular transport

Displaying 1 entry
Gene Ontology
GTP binding

Displaying **all 3** entries
InterPro
P-loop containing nucleoside triphosphate hydrolase
Small GTP-binding protein domain
Small GTPase

Rhea

H₂O + GTP

H⁺ + phosphate + GDP

Enzyme

PMID

Ortholog

Displaying entries **1 - 10** of 79 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	19342	Xenbase:XB-GENE-946075
Rattus norvegicus	50866		RATNO16664
Homo sapiens	53916		HUMAN43687
Danio rerio	445498		DANRE08210
Bos taurus	616314		BOVIN11125
Macaca mulatta	704173		MACMU18352
Monodelphis domestica	100015232		MONDO24765
Equus caballus	100064830		HORSE01639
Ciona intestinalis	100177325		CIOIN01477
Pongo abelii	100453299		PONAB15642

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Last updated: April 7, 2025