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ubiquitin protein ligase E3 component n-recognin 1

Summary

Gene Symbol

UBR1

Organism

Homo sapiens (human)

External Links

NCBI Gene

197131

PubChem

197131

Alliance of Genome Resources

HGNC:16808

JoGo

UBR1

TogoVar

UBR1

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Disease variant
Phosphoprotein
Proteomics identification
Reference proteome
Transferase
Ubl conjugation pathway
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8IWV7	N-recognin-1 Ubiquitin-protein ligase E3-alpha-1 Ubiquitin-protein ligase E3-alpha-I

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
protein ubiquitination	IBA
protein ubiquitination	IEA
negative regulation of TOR signaling	IMP	20298436
proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	15548684
cellular response to leucine	IDA	20298436

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein ubiquitination

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

modification-dependent macromolecule catabolic process [inference]

modification-dependent protein catabolic process [inference]

ubiquitin-dependent protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

proteasome-mediated ubiquitin-dependent protein catabolic process

ubiquitin-dependent protein catabolic process via the N-end rule pathway

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to stimulus [inference]

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to chemical [inference]

response to acid chemical [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

response to oxygen-containing compound [inference]

response to amino acid [inference]

response to leucine [inference]

cellular response to leucine

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to acid chemical [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to organic substance [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

cellular response to oxygen-containing compound [inference]

cellular response to amino acid stimulus [inference]

cellular response to leucine

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

Displaying **all 4** entries
GO Term	Evidence Code	PMID
ubiquitin ligase complex	IBA
proteasome complex	IEA
cytoplasm	IBA
cytosol	IDA	16311597

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

catalytic complex [inference]

peptidase complex [inference]

endopeptidase complex [inference]

proteasome complex

transferase complex [inference]

ubiquitin ligase complex

cellular anatomical entity [inference]

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16169070 21422291 28514442 32814053 33961781
zinc ion binding	IEA
ubiquitin protein ligase activity	IDA	15548684 18162545
ubiquitin protein ligase activity	IBA
leucine binding	IDA	20298436