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ryanodine receptor 1, skeletal muscle

Summary

Gene Symbol

Ryr1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20190

PubChem

20190

Alliance of Genome Resources

MGI:99659

Annotation

Keyword

3D-structure
ATP-binding
Calcium channel
Calmodulin-binding
Developmental protein
Ligand-gated ion channel
Metal-binding
Phosphoprotein
Receptor
Reference proteome
Repeat
S-nitrosylation
Sarcoplasmic reticulum
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
E9PZQ0	Skeletal muscle calcium release channel Skeletal muscle ryanodine receptor Skeletal muscle-type ryanodine receptor Type 1 ryanodine receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 30 in total

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GO Term	Evidence Code	PMID
response to hypoxia	ISO
outflow tract morphogenesis	IMP	18003898
calcium ion transport	ISO
calcium ion transport	IDA	12954602
intracellular calcium ion homeostasis	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to oxygen-containing compound [inference]

cellular response to salt [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

ossification [inference]

ossification involved in bone maturation

system process [inference]

muscle system process [inference]

muscle contraction

striated muscle contraction

developmental process [inference]

anatomical structure morphogenesis [inference]

outflow tract morphogenesis

anatomical structure development [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

animal organ development [inference]

skin development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

myotube cell development [inference]

skeletal muscle fiber development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

inorganic ion homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

regulation of cytosolic calcium ion concentration

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine

cellular response to caffeine

response to ATP [inference]

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to caffeine

cellular response to caffeine

response to ATP [inference]

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to organophosphorus [inference]

response to ATP [inference]

cellular response to ATP

response to calcium ion [inference]

cellular response to calcium ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to inorganic substance [inference]

response to metal ion [inference]

response to calcium ion [inference]

cellular response to calcium ion

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to oxygen-containing compound [inference]

cellular response to salt [inference]

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine

cellular response to caffeine

response to ATP [inference]

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to oxygen-containing compound [inference]

response to ATP [inference]

cellular response to ATP

response to calcium ion [inference]

cellular response to calcium ion

cellular response to oxygen-containing compound [inference]

response to salt [inference]

response to ATP [inference]

cellular response to ATP

response to calcium ion [inference]

cellular response to calcium ion

cellular response to salt [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to calcium ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to ATP

cellular response to purine-containing compound [inference]

cellular response to caffeine

cellular response to oxygen-containing compound [inference]

cellular response to salt [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport

sarcoplasmic reticulum calcium ion transport

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

organic substance transport [inference]

calcium ion transport

sarcoplasmic reticulum calcium ion transport

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of response to stress [inference]

regulation of response to osmotic stress

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

release of sequestered calcium ion into cytosol by endoplasmic reticulum [inference]

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction

Displaying entries **11 - 15** of 28 in total

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GO Term	Evidence Code	PMID
sarcoplasmic reticulum	IDA	11784029 12954602 15536090 7832748 8943043
sarcomere	ISO
Z disc	IBA
junctional membrane complex	IDA	10444070
T-tubule	IDA	15536090 22355118 23695157 8943043

GO Hierarchy

cellular component

protein-containing complex

junctional membrane complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated calcium channel complex [inference]

ryanodine receptor complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

voltage-gated calcium channel complex [inference]

ryanodine receptor complex

endoplasmic reticulum protein-containing complex [inference]

ryanodine receptor complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

calcium channel complex

voltage-gated calcium channel complex [inference]

ryanodine receptor complex

cellular anatomical entity [inference]

cytoplasm

cell cortex

membrane

plasma membrane

sarcolemma

organelle membrane

endoplasmic reticulum membrane [inference]

sarcoplasmic reticulum membrane

bounding membrane of organelle [inference]

sarcoplasmic reticulum membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of cytoplasmic side of plasma membrane

organelle subcompartment [inference]

endoplasmic reticulum subcompartment [inference]

terminal cisterna

organelle [inference]

membrane-bounded organelle [inference]

vesicle

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum [inference]

perinuclear region of cytoplasm

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

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GO Term	Evidence Code	PMID
protease binding	IPI	18676612
ryanodine-sensitive calcium-release channel activity	ISS
ryanodine-sensitive calcium-release channel activity	ISO
ryanodine-sensitive calcium-release channel activity	IMP	7621815
ryanodine-sensitive calcium-release channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation channel activity [inference]

calcium channel activity

voltage-gated calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

calcium channel activity

voltage-gated calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

voltage-gated calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

voltage-gated calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

monoatomic cation channel activity [inference]

calcium channel activity

voltage-gated calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated calcium channel activity

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

intracellular ligand-gated monoatomic ion channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

salt transmembrane transporter activity [inference]

calcium ion transmembrane transporter activity [inference]

calcium channel activity

voltage-gated calcium channel activity

ligand-gated calcium channel activity [inference]

calcium-release channel activity [inference]

calcium-induced calcium release activity

ryanodine-sensitive calcium-release channel activity

binding [inference]

protein binding

calmodulin binding

enzyme binding

protease binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ryanodine receptor

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
calcium channel activity
calcium ion transmembrane transport
calcium ion transport
calcium-mediated signaling
intracellular calcium ion homeostasis
monoatomic ion channel activity
monoatomic ion transport
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
ryanodine-sensitive calcium-release channel activity
striated muscle contraction

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InterPro
B30.2/SPRY domain superfamily
B30.2/SPRY domain
Concanavalin A-like lectin/glucanase domain superfamily
EF-hand domain pair
Inositol 1,4,5-trisphosphate/ryanodine receptor
Ion transport domain
MIR motif
Mir domain superfamily
RIH domain
RyR/IP3 receptor binding core, RIH domain superfamily

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0080991	congenital myopathy 1B	Alliance of Genome Resources
DOID:3529	congenital myopathy 1A	Alliance of Genome Resources
DOID:8545	malignant hyperthermia	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 58** of 58 in total

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Species	Gene ID	Orthologous MAtrix
Bos indicus x Bos taurus	113876549	BOBOX12425
Vombatus ursinus	114038136	VOMUR25367
Podarcis muralis	114603221	PODMU31787
Salmo trutta	115154755	SALTR104602
Salmo trutta	115204363	SALTR80240
Rhinolophus ferrumequinum	117034373	RHIFE00580
Balaenoptera musculus	118884703	BALMU16651
Panthera leo	122208926	PANLE29061

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements