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sodium channel, voltage-gated, type I, alpha

Summary

Gene Symbol

Scn1a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20265

PubChem

20265

Alliance of Genome Resources

MGI:98246

Annotation

Keyword

Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Phosphoprotein
Reference proteome
Repeat
Sodium channel
Transmembrane helix
Voltage-gated channel

Proteins

Displaying 1 entry
UniProt	Protein Name
A2APX8	Sodium channel protein brain I subunit alpha Sodium channel protein type I subunit alpha Voltage-gated sodium channel subunit alpha Nav1.1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
sodium ion transport	IMP	16921370 17928448
adult walking behavior	IMP	17537961 17928448
determination of adult lifespan	IMP	21156207
determination of adult lifespan	IGI	21156207
neuronal action potential propagation	IMP	17322896

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuronal action potential propagation

neuromuscular process [inference]

neuromuscular process controlling posture

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

determination of adult lifespan

developmental process [inference]

anatomical structure development [inference]

nerve development

response to stimulus [inference]

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

detection of mechanical stimulus involved in sensory perception of pain

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

establishment of localization in cell

biological regulation [inference]

regulation of biological quality [inference]

regulation of membrane potential

action potential [inference]

neuronal action potential

cardiac muscle cell action potential [inference]

cardiac muscle cell action potential involved in contraction

action potential propagation [inference]

neuronal action potential propagation

membrane depolarization [inference]

membrane depolarization during action potential

regulation of presynaptic membrane potential

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GO Term	Evidence Code	PMID
voltage-gated sodium channel complex	ISO
voltage-gated sodium channel complex	IBA
voltage-gated sodium channel complex	IEA
nucleoplasm	ISO
plasma membrane	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated sodium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

voltage-gated sodium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

sodium channel complex

voltage-gated sodium channel complex

cellular anatomical entity [inference]

nucleoplasm

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

axon initial segment

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
voltage-gated sodium channel activity	ISO
voltage-gated sodium channel activity	IDA	27281198
voltage-gated sodium channel activity	IMP	16921370
voltage-gated sodium channel activity	IBA
sodium ion binding	ISO

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

monoatomic cation channel activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity [inference]

voltage-gated sodium channel activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

alkali metal ion binding [inference]

sodium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

sodium channel protein

Functional Category

E: Amino acid transport and metabolism
K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
membrane depolarization during action potential
monoatomic ion channel activity
monoatomic ion transport
neuronal action potential
sodium channel activity
sodium ion transmembrane transport
voltage-gated sodium channel activity

Displaying **all 7** entries
InterPro
Ion transport domain
Sodium ion transport-associated domain
Voltage gated sodium channel, alpha subunit
Voltage-dependent channel domain superfamily
Voltage-gated Na+ ion channel, cytoplasmic domain
Voltage-gated cation channel calcium and sodium
Voltage-gated sodium channel alpha subunit, inactivation gate

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060041	autism spectrum disorder	Alliance of Genome Resources
DOID:0060170	generalized epilepsy with febrile seizures plus	Alliance of Genome Resources
DOID:0080422	Dravet syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **132** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	773	SGD:S000003449
Saccharomyces cerevisiae S288C	774	SGD:S000003449
Saccharomyces cerevisiae S288C	775	SGD:S000003449
Saccharomyces cerevisiae S288C	776	SGD:S000003449
Saccharomyces cerevisiae S288C	777	SGD:S000003449
Saccharomyces cerevisiae S288C	778	SGD:S000003449
Saccharomyces cerevisiae S288C	779	SGD:S000003449
Homo sapiens	6323	Xenbase:XB-GENE-978019	HUMAN65346
Xenopus tropicalis	6326	Xenbase:XB-GENE-978019
Xenopus tropicalis	6328	Xenbase:XB-GENE-978019