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sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Summary

Gene Symbol

Sema3c

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20348

PubChem

20348

Alliance of Genome Resources

MGI:107557

Annotation

Keyword

Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Neurogenesis
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q62181	Semaphorin-E

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
outflow tract septum morphogenesis	IGI IMP	26053665
positive regulation of cell migration	IBA
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis	IDA	26053665
axon guidance	IBA IDA	17021275
pulmonary myocardium development	IEP	19666519

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

cardiac endothelial to mesenchymal transition

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

somitogenesis

segmentation [inference]

somitogenesis

post-embryonic development

tissue remodeling [inference]

blood vessel remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

outflow tract morphogenesis

cardiac chamber morphogenesis [inference]

cardiac ventricle morphogenesis [inference]

cardiac right ventricle morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

dichotomous subdivision of an epithelial terminal unit [inference]

dichotomous subdivision of terminal units involved in salivary gland branching

cardiac septum morphogenesis [inference]

outflow tract septum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

neural tube development

muscle tissue development [inference]

striated muscle tissue development [inference]

pulmonary myocardium development

tube development [inference]

neural tube development

animal organ development [inference]

heart development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

cardiac endothelial to mesenchymal transition

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

biological regulation [inference]

regulation of biological process [inference]

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [inference]

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

semaphorin-plexin signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis [inference]

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	IBA
extracellular space	HDA IBA IDA	15239958 24006456
collagen-containing extracellular matrix	HDA	22159717

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

Displaying **all 3** entries
GO Term	Evidence Code	PMID
neuropilin binding	IBA
semaphorin receptor binding	IBA IPI	15239958
chemorepellent activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

chemorepellent activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **1 - 10** of **134** in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	6405	FB:FBgn0264273
Drosophila melanogaster	7869	FB:FBgn0264273
Drosophila melanogaster	9723	FB:FBgn0264273
Drosophila melanogaster	10371	FB:FBgn0264273
Drosophila melanogaster	10500	FB:FBgn0264273
Drosophila melanogaster	10501	FB:FBgn0264273
Caenorhabditis elegans	10505	WB:WBGene00004889
Drosophila melanogaster	10507	FB:FBgn0011260
Caenorhabditis elegans	10509	WB:WBGene00004889
Homo sapiens	10512	Xenbase:XB-GENE-1014800	HUMAN89607