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erythrocyte membrane protein band 4.1

Summary

Gene Symbol

EPB41

Organism

Homo sapiens (human)

External Links

NCBI Gene

2035

PubChem

2035

Alliance of Genome Resources

HGNC:3377

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Calmodulin-binding
Cytoskeleton
Direct protein sequencing
Elliptocytosis
Glycoprotein
Mitosis
Nucleus
Phosphoprotein
Proteomics identification
Pyropoikilocytosis
Reference proteome
Transport

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A2R8Y7Y3	Band 4.1 Erythrocyte membrane protein band 4.1
Q1WWM3	Band 4.1 Erythrocyte membrane protein band 4.1
P11171	4.1R Band 4.1 EPB4.1 Erythrocyte membrane protein band 4.1
Q59F12	Band 4.1 Erythrocyte membrane protein band 4.1
Q29RX4	Band 4.1 Erythrocyte membrane protein band 4.1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
actin cytoskeleton organization	NAS	8434260
cortical actin cytoskeleton organization	IEA
actomyosin structure organization	IBA
positive regulation of protein binding	IDA	3693401
cell division	IEA

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization

cell division

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

cortical cytoskeleton organization [inference]

cortical actin cytoskeleton organization

cellular component assembly [inference]

protein-containing complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport

regulation of intestinal absorption

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell cortex [inference]

positive regulation of protein localization to cell cortex

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of cellular localization [inference]

regulation of protein localization [inference]

positive regulation of protein localization [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell periphery [inference]

positive regulation of protein localization to cell cortex

regulation of protein localization to cell cortex [inference]

positive regulation of protein localization to cell cortex

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of digestive system process [inference]

regulation of intestinal absorption

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of binding [inference]

positive regulation of protein binding

regulation of binding [inference]

regulation of protein binding [inference]

positive regulation of protein binding

positive regulation of binding [inference]

positive regulation of protein binding

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA
cytoskeleton	IBA
plasma membrane	IDA
plasma membrane	IMP	6894932

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

cytoplasm [inference]

cell cortex

cytosol

membrane [inference]

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

spindle [inference]

mitotic spindle

cytoskeleton

intercellular bridge

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
actin binding	IEA
structural constituent of cytoskeleton	IMP	6894932
protein binding	IPI	10692436 11003675 16060676 16254212 16669616 20109190 23870127 24996901 25416956 32814053 8922391
calmodulin binding	IEA
1-phosphatidylinositol binding	IDA	16669616

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding [inference]

phosphoprotein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding [inference]

1-phosphatidylinositol binding

protein-containing complex binding [inference]

spectrin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

band 4.1-like protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
actin binding
cytoskeletal protein binding
structural molecule activity

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InterPro
Band 4.1 domain
Band 4.1, C-terminal
FERM adjacent
FERM central domain
FERM conserved site
FERM domain
FERM superfamily, second domain
FERM, C-terminal PH-like domain
FERM, N-terminal
FERM/acyl-CoA-binding protein superfamily

Ortholog

Displaying entries **1 - 10** of 69 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2035	Xenbase:XB-GENE-481625
Drosophila melanogaster	2036	FB:FBgn0010434
Drosophila melanogaster	2037	FB:FBgn0010434
Drosophila melanogaster	13821	FB:FBgn0010434
Drosophila melanogaster	13822	FB:FBgn0010434
Drosophila melanogaster	13823	FB:FBgn0010434
Drosophila melanogaster	23136	FB:FBgn0010434
Xenopus tropicalis	37205	Xenbase:XB-GENE-481625
Drosophila melanogaster	59317	FB:FBgn0010434
Mus musculus	269587		MOUSE40189