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sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

Summary

Gene Symbol

Sema6a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20358

PubChem

20358

Alliance of Genome Resources

MGI:1203727

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Neurogenesis
Phosphoprotein
Proteomics identification
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
O35464	Semaphorin Q Semaphorin VIA Semaphorin-6A-1
Q8BXZ7	Semaphorin VIA Semaphorin-6A-1
D3YWM8	Semaphorin VIA Semaphorin-6A-1
Q8BUT0	Semaphorin VIA Semaphorin-6A-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
neural crest cell migration	IBA
neuron migration	IMP	16205717
apoptotic process	NAS	10993894
cell surface receptor signaling pathway	IDA	18327254
axon guidance	NAS	10993894

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

semaphorin-plexin signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

neuron migration

microtubule organizing center localization [inference]

centrosome localization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to vascular endothelial growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to vascular endothelial growth factor stimulus

localization [inference]

microtubule organizing center localization [inference]

centrosome localization

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of vascular endothelial growth factor signaling pathway [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

regulation of neuron migration [inference]

positive regulation of neuron migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell adhesion involved in sprouting angiogenesis

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of cellular response to vascular endothelial growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of vascular endothelial growth factor signaling pathway [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of cellular response to vascular endothelial growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

negative regulation of cellular response to growth factor stimulus [inference]

negative regulation of cellular response to vascular endothelial growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of cellular response to vascular endothelial growth factor stimulus [inference]

regulation of vascular endothelial growth factor signaling pathway [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of cellular response to vascular endothelial growth factor stimulus [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

semaphorin-plexin signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of vascular endothelial growth factor signaling pathway [inference]

negative regulation of vascular endothelial growth factor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of ERK1 and ERK2 cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell adhesion involved in sprouting angiogenesis

regulation of cell adhesion involved in sprouting angiogenesis [inference]

negative regulation of cell adhesion involved in sprouting angiogenesis

positive regulation of cellular process [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell adhesion involved in sprouting angiogenesis

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of vascular endothelial growth factor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of MAPK cascade [inference]

negative regulation of ERK1 and ERK2 cascade

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

regulation of neuron migration [inference]

positive regulation of neuron migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of neuron migration

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis

negative regulation of sprouting angiogenesis

negative regulation of cell adhesion involved in sprouting angiogenesis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	20877282
plasma membrane	IBA
membrane	NAS	10993894
axon	NAS	10993894

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IMP	20877282
protein binding	IPI	10993894 20606624 20877282 20881961
semaphorin receptor binding	IGI	18327254
semaphorin receptor binding	IBA
semaphorin receptor binding	IPI	15814794 18327254