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ST3 beta-galactoside alpha-2,3-sialyltransferase 4

Summary

Gene Symbol

St3gal4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20443

KEGG Gene ID

mmu:20443

PubChem

20443

Alliance of Genome Resources

MGI:1316743

Annotation

Keyword

Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Lipid metabolism
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q91Y74	Alpha 2,3-sialyltransferase IV Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase N-acetyllactosaminide alpha-2,3-sialyltransferase ST3Gal IV Sialyltransferase 4C

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
protein glycosylation	ISO
protein glycosylation	IDA	9184827
protein glycosylation	IBA
protein glycosylation	IEA
glycoprotein biosynthetic process	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

lipid modification [inference]

lipid glycosylation

primary metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

lipid modification [inference]

lipid glycosylation

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

glycosylation [inference]

lipid glycosylation

macromolecule glycosylation [inference]

protein glycosylation

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

oligosaccharide metabolic process [inference]

oligosaccharide biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

lipid modification [inference]

lipid glycosylation

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

macromolecule modification [inference]

protein modification process [inference]

macromolecule glycosylation [inference]

protein glycosylation

sialylation

protein sialylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

carbohydrate derivative biosynthetic process [inference]

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process

protein modification process [inference]

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

carbohydrate biosynthetic process [inference]

oligosaccharide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

glycoprotein biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

glycolipid biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process

lipid modification [inference]

lipid glycosylation

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of locomotion [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of leukocyte adhesion to vascular endothelial cell [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte adhesion to vascular endothelial cell [inference]

positive regulation of leukocyte tethering or rolling

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of leukocyte migration [inference]

regulation of cellular extravasation [inference]

regulation of leukocyte tethering or rolling [inference]

positive regulation of leukocyte tethering or rolling

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

Displaying 1 entry
GO Term	Evidence Code	PMID
Golgi cisterna membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

Golgi cisterna membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	ISO
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IDA	9184827
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IBA
N-acetyllactosaminide alpha-2,3-sialyltransferase activity	ISS
N-acetyllactosaminide alpha-2,3-sialyltransferase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

sialyltransferase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Sialyltransferase

Functional Category

H: Coenzyme transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
sialyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
GT29-like superfamiliy
Glycosyl transferase family 29

KEGG BRITE Database

Orthology

K03494

Name

beta-galactoside alpha-2,3-sialyltransferase (sialyltransferase 4C) [EC:2.4.3.2 2.4.3.4 2.4.3.6]

References

8288606

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06153	2.4.3.6	G00049MO	G79536OW

Rhea

RHEA:52316

a β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→4)-N-acetyl-β-D-glucosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.6

PMID

RHEA:18913

a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-β-neuraminate

H⁺ + a neolactoside IV³-α-NeuAc-nLc4Cer(d18:1(4E)) + CMP

Enzyme

2.4.3.6

PMID

7130178

RHEA:18021

CMP-N-acetyl-β-neuraminate + a ganglioside GM1 (d18:1(4E))

H⁺ + CMP + a ganglioside GD1a (d18:1(4E))

Enzyme

2.4.3.2

PMID

RHEA:52380

a β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.2

PMID

RHEA:21616

a β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + CMP-N-acetyl-β-neuraminate

an N-acetyl-α-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-α-D-galactosaminyl derivative + H⁺ + CMP

Enzyme

2.4.3.4

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002996
Gene Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 4

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6484	Xenbase:XB-GENE-963280	HUMAN10176
Xenopus tropicalis	20443	Xenbase:XB-GENE-963280
Xenopus tropicalis	363040	Xenbase:XB-GENE-963280
Sus scrofa	396602		PIGXX35759
Xenopus tropicalis	403093	Xenbase:XB-GENE-963280
Bos taurus	404163		BOVIN23087
Pan troglodytes	466845		PANTR04703
Danio rerio	504044	Xenbase:XB-GENE-963280	DANRE14671
Canis lupus familiaris	607094		CANLF15096
Macaca mulatta	717792		MACMU09171

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements