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Guidelines

MIRAGE

solute carrier family 22 (organic cation transporter), member 2

Summary

Gene Symbol

Slc22a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20518

PubChem

20518

Alliance of Genome Resources

MGI:1335072

Annotation

Keyword

Alternative splicing
Cell membrane
Glycoprotein
Ion transport
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
O70577	Organic cation transporter 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 49 in total

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GO Term	Evidence Code	PMID
prostaglandin transport	ISO
amine transport	ISO
amine transport	IEA
putrescine transport	ISS
putrescine transport	ISO

GO Hierarchy

biological process

cellular process [inference]

transmembrane transport [inference]

vitamin transmembrane transport [inference]

thiamine transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

export across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

export from cell [inference]

export across plasma membrane

cellular detoxification

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

neurotransmitter transport

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

vascular transport [inference]

transport across blood-brain barrier [inference]

xenobiotic transport across blood-brain barrier

xenobiotic transport

xenobiotic transport across blood-brain barrier

vitamin transport [inference]

thiamine transport [inference]

thiamine transmembrane transport

vitamin transmembrane transport [inference]

thiamine transmembrane transport

transmembrane transport [inference]

vitamin transmembrane transport [inference]

thiamine transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

export across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic substance transport [inference]

lipid transport [inference]

fatty acid transport [inference]

prostaglandin transport

organic cation transport

norepinephrine transport

norepinephrine uptake

thiamine transport [inference]

thiamine transmembrane transport

quaternary ammonium group transport

organic anion transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

monocarboxylic acid transport [inference]

fatty acid transport [inference]

prostaglandin transport

icosanoid transport [inference]

prostaglandin transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

amine transport

monoamine transport [inference]

serotonin transport

serotonin uptake

catecholamine transport [inference]

dopamine transport

dopamine uptake

norepinephrine transport

norepinephrine uptake

epinephrine transport

catecholamine uptake [inference]

polyamine transport [inference]

putrescine transport

organic acid transport [inference]

carboxylic acid transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

monocarboxylic acid transport [inference]

fatty acid transport [inference]

prostaglandin transport

icosanoid transport [inference]

prostaglandin transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic hydroxy compound transport [inference]

serotonin transport

serotonin uptake

catecholamine transport [inference]

dopamine transport

dopamine uptake

norepinephrine transport

norepinephrine uptake

epinephrine transport

catecholamine uptake [inference]

azole transmembrane transport [inference]

thiamine transmembrane transport

histamine transport

histamine uptake

modified amino acid transport [inference]

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

acetate ester transport [inference]

acetylcholine transport

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

amino acid import across plasma membrane

L-arginine import across plasma membrane

L-alpha-amino acid transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport

quaternary ammonium group transport

amine transport

monoamine transport [inference]

serotonin transport

serotonin uptake

catecholamine transport [inference]

dopamine transport

dopamine uptake

norepinephrine transport

norepinephrine uptake

epinephrine transport

catecholamine uptake [inference]

polyamine transport [inference]

putrescine transport

thiamine transport [inference]

thiamine transmembrane transport

azole transmembrane transport [inference]

thiamine transmembrane transport

histamine transport

histamine uptake

modified amino acid transport [inference]

pyrimidine-containing compound transmembrane transport [inference]

thiamine transmembrane transport

sulfur compound transport [inference]

thiamine transport [inference]

thiamine transmembrane transport

import into cell [inference]

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

amino acid import across plasma membrane

L-arginine import across plasma membrane

export from cell [inference]

export across plasma membrane

establishment of localization in cell [inference]

neurotransmitter reuptake [inference]

serotonin uptake

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

detoxification [inference]

cellular detoxification

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO	12176030
basal plasma membrane	ISS
basal plasma membrane	ISO
basolateral plasma membrane	ISS
basolateral plasma membrane	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

cell junction [inference]

synapse [inference]

cholinergic synapse

presynapse

Displaying entries **1 - 5** of 36 in total

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GO Term	Evidence Code	PMID
amine transmembrane transporter activity	ISO
amine transmembrane transporter activity	IEA
acetylcholine transmembrane transporter activity	ISS
acetylcholine transmembrane transporter activity	ISO
neurotransmitter transmembrane transporter activity	ISS

GO Hierarchy

molecular function

transporter activity [inference]

lipid transporter activity [inference]

icosanoid transmembrane transporter activity [inference]

prostaglandin transmembrane transporter activity

transmembrane transporter activity [inference]

amine transmembrane transporter activity

neurotransmitter transmembrane transporter activity

acetylcholine transmembrane transporter activity

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

basic amino acid transmembrane transporter activity [inference]

L-arginine transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-arginine transmembrane transporter activity

organic anion transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

basic amino acid transmembrane transporter activity [inference]

L-arginine transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-arginine transmembrane transporter activity

organic cation transmembrane transporter activity

quaternary ammonium group transmembrane transporter activity

polyamine transmembrane transporter activity [inference]

putrescine transmembrane transporter activity

efflux transmembrane transporter activity

nucleobase-containing compound transmembrane transporter activity [inference]

nucleoside transmembrane transporter activity [inference]

pyrimidine nucleoside transmembrane transporter activity

toxin transmembrane transporter activity

active transmembrane transporter activity [inference]

monoamine transmembrane transporter activity

xenobiotic transmembrane transporter activity

icosanoid transmembrane transporter activity [inference]

prostaglandin transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

L-arginine transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

thiamine transmembrane transporter activity

acetate ester transmembrane transporter activity [inference]

acetylcholine transmembrane transporter activity

azole transmembrane transporter activity [inference]

thiamine transmembrane transporter activity

carbohydrate derivative transmembrane transporter activity [inference]

nucleoside transmembrane transporter activity [inference]

pyrimidine nucleoside transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

thiamine transmembrane transporter activity

salt transmembrane transporter activity [inference]

binding [inference]

lipid binding [inference]

steroid binding

organic cyclic compound binding [inference]

steroid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Solute carrier family 22 member 22

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026