GlyCosmos Portal

Annotation

Keyword

Cell membrane
Glycoprotein
Phosphoprotein
Reference proteome
Sugar transport
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P14246	Glucose transporter type 2, liver

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
carbohydrate utilization	ISO
glucose import	IBA
carbohydrate transport	TAS
cellular response to organic cyclic compound	ISO
positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP	10823833 10969832

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic cyclic compound

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport

glucose import

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

carbohydrate utilization

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

cellular response to organic cyclic compound

response to lipid [inference]

response to fatty acid [inference]

cellular response to fatty acid

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic cyclic compound

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic cyclic compound

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

response to oxygen-containing compound [inference]

response to fatty acid [inference]

cellular response to fatty acid

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to lipid [inference]

cellular response to fatty acid

cellular response to organic cyclic compound

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid

localization [inference]

establishment of localization [inference]

transport [inference]

vitamin transport [inference]

dehydroascorbic acid transport

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport

glucose import

organic substance transport [inference]

carbohydrate transport

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

glucose transmembrane transport

glucose import

organic anion transport [inference]

dehydroascorbic acid transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide transport [inference]

regulation of peptide secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of peptide secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein localization [inference]

positive regulation of establishment of protein localization [inference]

positive regulation of protein transport [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of protein secretion [inference]

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of secretion by cell [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of protein secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

positive regulation of hormone secretion [inference]

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of peptide hormone secretion [inference]

regulation of insulin secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

regulation of insulin secretion involved in cellular response to glucose stimulus [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

positive regulation of peptide hormone secretion [inference]

positive regulation of insulin secretion [inference]

positive regulation of insulin secretion involved in cellular response to glucose stimulus

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
apical plasma membrane	IDA ISO	19841136
plasma membrane	IBA IDA ISO TAS	12921743 14702043 14736883 18511518
endosome	ISO
brush border	IBA IDA ISO
cell-cell junction	IDA	11287626 17928203

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

brush border membrane

cell junction [inference]

anchoring junction [inference]

cell-cell junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome

cluster of actin-based cell projections [inference]

brush border

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
D-glucose transmembrane transporter activity	IBA IDA ISO TAS	10823833 18668520

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic anion transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

carbohydrate transmembrane transporter activity [inference]

sugar transmembrane transporter activity [inference]

monosaccharide transmembrane transporter activity [inference]

hexose transmembrane transporter activity [inference]

glucose transmembrane transporter activity

D-glucose transmembrane transporter activity

vitamin transmembrane transporter activity [inference]

dehydroascorbic acid transmembrane transporter activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

insulin receptor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

solute carrier family 2, facilitated glucose transporter member 2

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
hexose transmembrane transporter activity
organic substance transport

Displaying **all 7** entries
InterPro
Glucose transporter GLUT
Glucose transporter, type 2 (GLUT2)
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator, sugar transporter-like
Sugar transporter, conserved site
Sugar/inositol transporter

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:2747	glycogen storage disease	Alliance of Genome Resources
DOID:3892	insulinoma	Alliance of Genome Resources
DOID:5577	gastrinoma	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **71 - 80** of **121** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Sinocyclocheilus grahami	107550598		SINGR71474
Sinocyclocheilus grahami	107586013		SINGR01585
Ictalurus punctatus	108278343		ICTPU09633
Crocodylus porosus	109308434		CROPO15170
Castor canadensis	109682261	51338_0:000c94
Phascolarctos cinereus	110203994		PHACI10517
Mus caroli	110291094	10089_0:000c1f
Mus pahari	110320473	10093_0:001465
Meriones unguiculatus	110545687	10047_0:000a42
Vulpes vulpes	112926672		VULVU21030

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements