GlyCosmos Portal

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Aromatic hydrocarbons catabolism
Cytoplasm
Detoxification
Direct protein sequencing
Hydrolase
Lipid metabolism
Lipoprotein
Magnesium
Metal-binding
Multifunctional enzyme
Peroxisome
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P34913

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
epoxide metabolic process	IDA	21217101 22798687
dephosphorylation	IDA	12574508 22217705
cholesterol homeostasis	IBA IDA	18974052
stilbene catabolic process	IDA	8342951
regulation of cholesterol metabolic process	IMP	18974052

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

organic substance catabolic process [inference]

olefinic compound catabolic process [inference]

stilbene catabolic process

organic cyclic compound catabolic process [inference]

stilbene catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

benzene-containing compound metabolic process [inference]

stilbene metabolic process [inference]

stilbene catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation

phospholipid dephosphorylation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

cellular lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation

heterocycle metabolic process [inference]

epoxide metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation

small molecule metabolic process [inference]

ether metabolic process [inference]

epoxide metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation

ether metabolic process [inference]

epoxide metabolic process

olefinic compound metabolic process [inference]

stilbene metabolic process [inference]

stilbene catabolic process

olefinic compound catabolic process [inference]

stilbene catabolic process

organic cyclic compound metabolic process [inference]

benzene-containing compound metabolic process [inference]

stilbene metabolic process [inference]

stilbene catabolic process

epoxide metabolic process

organic cyclic compound catabolic process [inference]

stilbene catabolic process

organic substance catabolic process [inference]

olefinic compound catabolic process [inference]

stilbene catabolic process

organic cyclic compound catabolic process [inference]

stilbene catabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

benzene-containing compound metabolic process [inference]

stilbene metabolic process [inference]

stilbene catabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

dephosphorylation

phospholipid dephosphorylation

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

stilbene catabolic process

cellular lipid metabolic process [inference]

lipid modification [inference]

phospholipid dephosphorylation

heterocycle metabolic process [inference]

epoxide metabolic process

homeostatic process [inference]

chemical homeostasis [inference]

lipid homeostasis [inference]

sterol homeostasis [inference]

cholesterol homeostasis

response to stimulus [inference]

response to chemical [inference]

response to toxic substance

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of small molecule metabolic process [inference]

regulation of cholesterol metabolic process

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of steroid metabolic process [inference]

regulation of cholesterol metabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

positive regulation of gene expression

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	IDA TAS	16314446 18513744 8342951
peroxisome	IBA IDA	16314446 18513744
peroxisomal matrix
extracellular exosome	HDA	19056867 23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

microbody lumen [inference]

peroxisomal matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
phosphatase activity	IDA	12574508 15196990
magnesium ion binding	IBA IDA	12574510
protein homodimerization activity	IDA	15096040 18513744
toxic substance binding	IDA	15096040
10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity

hydrolase activity, acting on ether bonds [inference]

ether hydrolase activity [inference]

epoxide hydrolase activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

toxic substance binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000120915

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K08726

Name

soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76]

References

Disease

Disease Ontology

Displaying entries **1 - 10** of **121** in total

1

2

3

4

5

…

Next ›

Last »
DO ID	Disease Name	Source
DOID:0050457	Sertoli cell-only syndrome	DisGeNET
DOID:0050535	exudative vitreoretinopathy	DisGeNET
DOID:0050589	inflammatory bowel disease	DisGeNET DisGeNET
DOID:0060041	autism spectrum disorder	DisGeNET
DOID:0060058	lymphoma	DisGeNET
DOID:0060060	non-Hodgkin lymphoma	DisGeNET
DOID:0060192	Crohn's colitis	DisGeNET
DOID:0060224	atrial fibrillation	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET

The Human Phenotype Ontology

Displaying **all 7** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0001084	Corneal arcus
HP:0001114	Xanthelasma
HP:0001677	Coronary artery atherosclerosis
HP:0003141	Increased LDL cholesterol concentration
HP:0010874	Tendon xanthomatosis

Displaying 1 entry
Disease ID	Disease Name
OMIM:143890	hypercholesterolemia, familial, 1

PubChem Disease

MedGen Diseases

Hypercholesterolemia, familial, 1

OMIM Phenotypes

HYPERCHOLESTEROLEMIA, FAMILIAL, 1; FHCL1

KEGG Diseases

Familial hypercholesterolemia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP003143
Gene Name: epoxide hydrolase 2, cytoplasmic

Ortholog

Displaying entries **1 - 10** of 66 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Danio rerio	494099	ZFIN:ZDB-GENE-041212-70	DANRE11764
Astyanax mexicanus	103037948		ASTMX08170
Ictalurus punctatus	108270338		ICTPU35660
Electrophorus electricus	113572683		ELEEL13382
Salmo salar	106611412		SALSA139810
Salmo trutta	115161918		SALTR57189
Salmo trutta	115172954		SALTR71867
Oryzias latipes	101157276		ORYLA08551
Oreochromis niloticus	100705182		ORENI44876
Sparus aurata	115577027		SPAAU66978

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements