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slit guidance ligand 3

Summary

Gene Symbol

Slit3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20564

PubChem

20564

Alliance of Genome Resources

MGI:1315202

Annotation

Keyword

Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Leucine-rich repeat
Neurogenesis
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying **all 4** entries
UniProt	Protein Name
Q3UHN1
B2RX06
Q9WVB4
Q9Z0Y6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
Roundabout signaling pathway	IEA ISO
negative regulation of cell growth	IEA ISO
aortic valve morphogenesis	IMP	25691540
negative chemotaxis	IBA IEA ISO
negative regulation of cell population proliferation	IGI	18829537

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Roundabout signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

apoptotic process involved in development [inference]

apoptotic process involved in luteolysis

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

cellular process involved in reproduction in multicellular organism [inference]

apoptotic process involved in luteolysis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance

reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

apoptotic process involved in luteolysis

developmental process [inference]

anatomical structure morphogenesis [inference]

heart valve morphogenesis [inference]

animal organ morphogenesis

cardiac septum morphogenesis [inference]

ventricular septum morphogenesis

growth [inference]

cell growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth [inference]

developmental cell growth [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

developmental growth involved in morphogenesis [inference]

neuron projection extension [inference]

axon extension [inference]

axon extension involved in axon guidance

neuron projection extension involved in neuron projection guidance [inference]

axon extension involved in axon guidance

locomotion [inference]

taxis [inference]

chemotaxis [inference]

negative chemotaxis

response to stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisol

cellular response to endogenous stimulus [inference]

cellular response to hormone stimulus

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

cellular response to hormone stimulus

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisol

response to organic cyclic compound [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisol

response to lipid [inference]

response to steroid hormone [inference]

response to corticosteroid [inference]

response to glucocorticoid [inference]

response to cortisol

cellular response to organic substance [inference]

cellular response to hormone stimulus

response to alcohol [inference]

response to cortisol

response to ketone [inference]

response to cortisol

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

response to oxygen-containing compound [inference]

response to alcohol [inference]

response to cortisol

response to ketone [inference]

response to cortisol

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to hormone stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of cell growth

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of cell growth

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of response to cytokine stimulus [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Roundabout signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of chemokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of cytokine-mediated signaling pathway [inference]

negative regulation of chemokine-mediated signaling pathway

negative regulation of cell growth

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression

regulation of cellular component organization [inference]

regulation of cell growth [inference]

negative regulation of cell growth

Displaying **all 3** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
extracellular region
extracellular space	HDA IDA ISO	12954717 24006456

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
heparin binding	IBA
signaling receptor binding	TAS	12954717
Roundabout binding	IBA IEA ISO
calcium ion binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding

Roundabout binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

heparin binding

sulfur compound binding [inference]

heparin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

slit homolog 3 protein

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
Roundabout binding
calcium ion binding
cell differentiation
heparin binding
negative chemotaxis
nervous system development
signaling receptor binding

Displaying entries **1 - 10** of 12 in total

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InterPro
Concanavalin A-like lectin/glucanase domain superfamily
Cysteine-rich flanking region, C-terminal
Cystine knot, C-terminal
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
Laminin G domain
Leucine-rich repeat N-terminal domain
Leucine-rich repeat domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:3827	congenital diaphragmatic hernia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	6586		HGNC:11087	HUMAN82184
Drosophila melanogaster	36746		FB:FBgn0264089
Danio rerio	80354		ZFIN:ZDB-GENE-010306-4	DANRE06975
Rattus norvegicus	83467	10116_1:003aa8	RGD:69311	RATNO03061
Pan troglodytes	462359			PANTR36782
Bos taurus	615883			BOVIN15693
Macaca mulatta	703950			MACMU38447
Xenopus tropicalis	780195		Xenbase:XB-GENE-991050
Monodelphis domestica	100030923			MONDO07617
Equus caballus	100070488			HORSE08929

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements