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MIRAGE

epidermal growth factor receptor pathway substrate 15

Summary

Gene Symbol

EPS15

Organism

Homo sapiens (human)

External Links

NCBI Gene

2060

KEGG Gene ID

PubChem

2060

Alliance of Genome Resources

HGNC:3419

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Calcium
Cell membrane
Chromosomal rearrangement
Coated pit
Coiled coil
Cytoplasm
Endocytosis
Endosome
Host-virus interaction
Metal-binding
Phosphoprotein
Protein transport
Proteomics identification
Proto-oncogene
Receptor
Reference proteome
Repeat
SH3-binding
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A994J5A3	Protein AF-1p
A0A994J5J3	Protein AF-1p
B7Z240
P42566	Protein AF-1p

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 16 in total

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GO Term	Evidence Code	PMID
vesicle organization	TAS
endosomal transport	IBA
receptor-mediated endocytosis of virus by host cell	IMP
endocytic recycling	IC
endocytic recycling	IEA

GO Hierarchy

biological process

cellular process [inference]

intercellular transport [inference]

Golgi to endosome transport

vesicle-mediated transport [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

ubiquitin-dependent endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

endosomal transport

endocytic recycling

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

vesicle-mediated transport in synapse [inference]

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

endosomal transport

endocytic recycling

cytosolic transport [inference]

Golgi to endosome transport

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

symbiont entry into host [inference]

symbiont entry into host cell

endocytosis involved in viral entry into host cell [inference]

receptor-mediated endocytosis of virus by host cell

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

ubiquitin-dependent endocytosis

protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

Golgi to endosome transport

protein transport

ubiquitin-dependent endocytosis

vesicle-mediated transport [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

ubiquitin-dependent endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

endosomal transport

endocytic recycling

Golgi vesicle transport [inference]

post-Golgi vesicle-mediated transport [inference]

Golgi to endosome transport

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

vesicle-mediated transport in synapse [inference]

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

intracellular transport [inference]

endosomal transport

endocytic recycling

cytosolic transport [inference]

Golgi to endosome transport

import into cell [inference]

receptor-mediated endocytosis [inference]

receptor-mediated endocytosis of virus by host cell

receptor internalization [inference]

neurotransmitter receptor internalization [inference]

postsynaptic neurotransmitter receptor internalization

ubiquitin-dependent endocytosis

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

establishment of protein localization [inference]

protein transport

ubiquitin-dependent endocytosis

establishment of protein localization to organelle [inference]

ubiquitin-dependent endocytosis

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport

endocytic recycling

cytosolic transport [inference]

Golgi to endosome transport

postsynaptic endocytosis [inference]

postsynaptic neurotransmitter receptor internalization

cellular localization [inference]

intracellular transport [inference]

endosomal transport

endocytic recycling

cytosolic transport [inference]

Golgi to endosome transport

localization within membrane [inference]

vesicle-mediated transport to the plasma membrane [inference]

endocytic recycling

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

positive regulation of signaling [inference]

positive regulation of receptor recycling

regulation of localization [inference]

regulation of protein localization

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of receptor recycling

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of macromolecule metabolic process [inference]

regulation of receptor recycling [inference]

positive regulation of receptor recycling

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of receptor recycling

regulation of biological quality [inference]

regulation of postsynaptic membrane neurotransmitter receptor levels [inference]

postsynaptic neurotransmitter receptor internalization

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA
early endosome	IEA
cytosol	TAS
cytosol	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

membrane coat [inference]

clathrin coat [inference]

clathrin coat of coated pit

AP-type membrane coat adaptor complex [inference]

clathrin adaptor complex [inference]

AP-2 adaptor complex

plasma membrane protein complex [inference]

cellular anatomical structure [inference]

intracellular anatomical structure [inference]

inclusion body [inference]

aggresome

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

cell junction [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

coated vesicle [inference]

clathrin-coated vesicle

postsynaptic endocytic zone

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI
SH3 domain binding
protein-macromolecule adaptor activity	IBA
polyubiquitin modification-dependent protein binding	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein domain specific binding [inference]

SH3 domain binding

ubiquitin-like protein binding [inference]

ubiquitin binding

identical protein binding

cell adhesion molecule binding [inference]

cadherin binding

modification-dependent protein binding [inference]

polyubiquitin modification-dependent protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Saccharomyces cerevisiae S288C	852233	SGD:S000000143
Drosophila melanogaster	37961	FB:FBgn0035060

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026