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serine protease inhibitor, Kunitz type 2

Summary

Gene Symbol

Spint2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20733

PubChem

20733

Alliance of Genome Resources

MGI:1338031

Annotation

Keyword

Alternative splicing
Cell membrane
Cytoplasm
Disulfide bond
Glycoprotein
Reference proteome
Repeat
Serine protease inhibitor
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9WU03	Hepatocyte growth factor activator inhibitor type 2
Q9D8Q8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
neural tube closure	IGI IMP	19592578
negative regulation of cell motility	ISO
basement membrane organization	IMP	19592578

GO Hierarchy

biological process

cellular process [inference]

establishment or maintenance of cell polarity

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

basement membrane organization

reproductive process [inference]

developmental process involved in reproduction [inference]

epithelial cell morphogenesis involved in placental branching

developmental process [inference]

developmental process involved in reproduction [inference]

epithelial cell morphogenesis involved in placental branching

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

epithelial cell morphogenesis [inference]

epithelial cell morphogenesis involved in placental branching

embryonic morphogenesis [inference]

epithelial cell morphogenesis involved in placental branching

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of locomotion [inference]

negative regulation of locomotion [inference]

negative regulation of cell motility

regulation of cell motility [inference]

negative regulation of cell motility

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of locomotion [inference]

negative regulation of cell motility

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion

negative regulation of cell population proliferation [inference]

negative regulation of neural precursor cell proliferation

negative regulation of cell motility

regulation of cellular process [inference]

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of neural precursor cell proliferation

regulation of neural precursor cell proliferation [inference]

negative regulation of neural precursor cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion

negative regulation of cell population proliferation [inference]

negative regulation of neural precursor cell proliferation

negative regulation of cell motility

regulation of cell motility [inference]

negative regulation of cell motility

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying **all 3** entries
GO Term	Evidence Code	PMID
membrane
plasma membrane	IEA
cytoplasm	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

plasma membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
serine-type endopeptidase inhibitor activity	IBA IEA ISO

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

kunitz-type protease inhibitor 2

Functional Category

E: Amino acid transport and metabolism
K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
serine-type endopeptidase inhibitor activity

Displaying **all 3** entries
InterPro
Pancreatic trypsin inhibitor Kunitz domain superfamily
Pancreatic trypsin inhibitor Kunitz domain
Proteinase inhibitor I2, Kunitz, conserved site

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060781	congenital secretory sodium diarrhea 3	Alliance of Genome Resources
DOID:13608	biliary atresia	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 80 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Octodon degus	101571084	10160_0:002a2d		OCTDE14915
Jaculus jaculus	101614970	51337_0:002612		JACJA11318
Mustela putorius furo	101690445			MUSPF03310
Heterocephalus glaber	101704151	10181_0:002e54		HETGA11350
Mesocricetus auratus	101839885	10036_0:0042ca
Ictidomys tridecemlineatus	101977153	43179_0:004dfb		ICTTR04252
Microtus ochrogaster	101990927	79684_0:0032aa
Chinchilla lanigera	102020551	34839_0:0031fd		CHILA16420
Macaca fascicularis	102145018			MACFA18126
Capra hircus	102175430			CAPHI08937

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024