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MIRAGE
AKT serine/threonine kinase 2

Summary
Gene Symbol
  • AKT2
Organism
Homo sapiens (human)
NCBI Gene
208
PubChem
208
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Alternative splicing
  • Apoptosis
  • Cell membrane
  • Cytoplasm
  • Developmental protein
  • Diabetes mellitus
  • Disease variant
  • Disulfide bond
  • Endosome
  • Glucose metabolism
  • Glycogen biosynthesis
  • Glycogen metabolism
  • Glycoprotein
  • Manganese
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Proto-oncogene
  • Reference proteome
  • Serine/threonine-protein kinase
  • Sugar transport
  • Translation regulation
  • Ubl conjugation
Proteins
Displaying all 2 entries
UniProt Protein Name
P31751
  • Protein kinase Akt-2
  • Protein kinase B beta
  • RAC protein kinase beta
B4DG79
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 29 in total
GO Term Evidence Code PMID
glycogen biosynthetic process
glucose metabolic process
chromatin remodeling
protein phosphorylation
signal transduction
GO Hierarchy
Displaying entries 1 - 5 of 28 in total
GO Term Evidence Code PMID
protein serine/threonine kinase activity
protein serine/threonine kinase activity
protein serine/threonine kinase activity
3-phosphoinositide-dependent protein kinase activity
DNA-dependent protein kinase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
Kinase
Functional Category
  • E: Amino acid transport and metabolism
  • J: Translation, ribosomal structure and biogenesis
  • T: Signal transduction mechanisms
Displaying all 5 entries
Gene Ontology
ATP binding
kinase activity
nucleotide binding
phosphorylation
transferase activity
Displaying all 9 entries
InterPro
AGC-kinase, C-terminal
PH-like domain superfamily
Pleckstrin homology domain
Protein Kinase B, pleckstrin homology domain
Protein kinase domain
Protein kinase, ATP binding site
Protein kinase, C-terminal
Protein kinase-like domain superfamily
Serine/threonine-protein kinase, active site
Disease
Disease Ontology
Displaying all 8 entries
DO ID Disease Name Source
DOID:0112263 hypoinsulinemic hypoglycemia with hemihypertrophy
DOID:10283 prostate cancer
DOID:10286 prostate carcinoma
DOID:1380 endometrial cancer
DOID:2526 prostate adenocarcinoma
DOID:4001 ovarian carcinoma
DOID:9352 type 2 diabetes mellitus
DOID:9993 hypoglycemia
Ortholog
Displaying entries 1 - 10 of 77 in total
Species Gene ID Alliance of Genome Resources Orthologous MAtrix
207 SGD:S000001248
208 Xenbase:XB-GENE-484168
10000 SGD:S000001248
11651 FB:FBgn0010379
11652 Xenbase:XB-GENE-484168 MOUSE52616
23797 FB:FBgn0010379
24185 FB:FBgn0010379
25233 Xenbase:XB-GENE-484168 RATNO15597
29414 FB:FBgn0010379
378972 DANRE14281
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025