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B and T lymphocyte associated

Summary

Gene Symbol

Btla

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

208154

PubChem

208154

Alliance of Genome Resources

MGI:2658978

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Proteomics identification
Receptor
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0R4J1A0
Q32MV8
E9QNY6
Q7TSA3	B- and T-lymphocyte-associated protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

1

2

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GO Term	Evidence Code	PMID
immune response-regulating cell surface receptor signaling pathway	IBA IMP	15568026
cell surface receptor signaling pathway	IDA	15568026
negative regulation of T cell proliferation	IMP	12796776
adaptive immune response	IEA
negative regulation of B cell proliferation	IMP	12796776

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

adaptive immune response

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway

cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway

response to stimulus [inference]

immune response [inference]

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of response to stimulus [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway

cell surface receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of cell-cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of leukocyte cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-cell adhesion [inference]

negative regulation of leukocyte cell-cell adhesion [inference]

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of cell population proliferation [inference]

negative regulation of leukocyte proliferation [inference]

negative regulation of mononuclear cell proliferation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of T cell activation [inference]

regulation of T cell proliferation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of alpha-beta T cell proliferation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation [inference]

negative regulation of B cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of cell activation [inference]

negative regulation of leukocyte activation [inference]

negative regulation of lymphocyte activation [inference]

negative regulation of lymphocyte proliferation [inference]

negative regulation of B cell proliferation

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of T cell activation [inference]

negative regulation of T cell proliferation

negative regulation of alpha-beta T cell proliferation

negative regulation of alpha-beta T cell activation [inference]

negative regulation of alpha-beta T cell proliferation

negative regulation of B cell activation [inference]

negative regulation of B cell proliferation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
external side of plasma membrane	IDA	15568026
plasma membrane	IBA IDA TAS	12796776

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	12796776 15568026
signaling receptor activity	IBA IGI	12920180

GO Hierarchy

molecular function

binding [inference]

protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

B- and T-lymphocyte attenuator

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
Gene Ontology
immune response-regulating cell surface receptor signaling pathway

Displaying **all 5** entries
InterPro
B- and T-lymphocyte attenuator
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **1 - 10** of 83 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	151888		HGNC:21087	HUMAN71498
Rattus norvegicus	407756	10116_1:003d3b	RGD:1303280	RATNO04114
Pan troglodytes	460584			PANTR31830
Canis lupus familiaris	487975			CANLF13291
Bos taurus	531767			BOVIN14487
Macaca mulatta	708202			MACMU28266
Equus caballus	100071491			HORSE14500
Callithrix jacchus	100407622			CALJA11591
Pongo abelii	100432095			PONAB25920
Nomascus leucogenys	100586804			NOMLE20080

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements