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signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

Summary

Gene Symbol

Stam

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20844

PubChem

20844

Alliance of Genome Resources

MGI:1329014

Annotation

Keyword

Cytoplasm
Endosome
Isopeptide bond
Membrane
Phosphoprotein
Protein transport
Reference proteome
SH3 domain
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3TQ49
P70297

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
regulation of extracellular exosome assembly	IEA ISO
protein transport	IEA
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA
positive regulation of exosomal secretion	IEA ISO

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

multivesicular body sorting pathway [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

organic substance transport [inference]

protein transport

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

nitrogen compound transport [inference]

protein transport

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

vacuolar transport [inference]

late endosome to vacuole transport [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

endosomal transport [inference]

endosome transport via multivesicular body sorting pathway [inference]

late endosome to vacuole transport via multivesicular body sorting pathway [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

protein localization to vacuole [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

positive regulation of transport [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of exosomal secretion

regulation of organelle assembly [inference]

regulation of extracellular exosome assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of organelle assembly [inference]

regulation of extracellular exosome assembly

regulation of vesicle-mediated transport [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

regulation of secretion by cell [inference]

regulation of exocytosis [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

regulation of exosomal secretion [inference]

positive regulation of exosomal secretion

positive regulation of secretion by cell [inference]

positive regulation of exocytosis [inference]

positive regulation of exosomal secretion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
intracellular membrane-bounded organelle	ISO
ESCRT-0 complex	IBA IEA ISO
early endosome membrane	IEA
cytosol	IEA ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

ESCRT complex [inference]

ESCRT-0 complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane [inference]

early endosome membrane

bounding membrane of organelle [inference]

endosome membrane [inference]

early endosome membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10982817
phosphatidylinositol binding	IEA
ubiquitin-like protein ligase binding	IEA ISO
ubiquitin binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding

ubiquitin-like protein binding [inference]

ubiquitin binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylinositol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

signal transducing adapter molecule 1

Functional Category

J: Translation, ribosomal structure and biogenesis
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
phosphatidylinositol binding
protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
ubiquitin binding

Displaying **all 8** entries
InterPro
ENTH/VHS
SH3 domain
SH3-like domain superfamily
STAM1, SH3 domain
STAM1, VHS domain
STAM1, non-canonical GAT domain
Ubiquitin interacting motif
VHS domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080322	polycystic kidney disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **121** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8027		HGNC:11357	HUMAN00438
Drosophila melanogaster	34505		FB:FBgn0027363
Caenorhabditis elegans	172264		WB:WBGene00004109
Danio rerio	386967		ZFIN:ZDB-GENE-031118-123	DANRE29496
Xenopus tropicalis	394846		Xenbase:XB-GENE-482429
Pan troglodytes	466269			PANTR00253
Canis lupus familiaris	477990			CANLF06528
Rattus norvegicus	498798	10116_1:004b37	RGD:1564499	RATNO12214
Bos taurus	512734			BOVIN04475
Macaca mulatta	706026			MACMU44936

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Summary

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements