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synaptojanin 2

Summary

Gene Symbol

Synj2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

20975

PubChem

20975

Alliance of Genome Resources

MGI:1201671

Annotation

Keyword

Alternative splicing
Cell membrane
Cell projection
Cytoskeleton
Hydrolase
Lipid metabolism
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Synapse

Proteins

Displaying **all 5** entries
UniProt	Protein Name
Q9D2G5	Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2
Q3TTB3
F8WHD8
E9Q4P5
D3YZB2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
inositol phosphate catabolic process	ISO
phosphatidylinositol dephosphorylation	IEA ISO
synaptic vesicle endocytosis	IBA ISO

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

inositol phosphate catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate catabolic process [inference]

inositol phosphate catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

polyol catabolic process [inference]

inositol phosphate catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

small molecule catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate catabolic process [inference]

inositol phosphate catabolic process

organic substance catabolic process [inference]

organophosphate catabolic process [inference]

inositol phosphate catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

polyol catabolic process [inference]

inositol phosphate catabolic process

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

organic hydroxy compound catabolic process [inference]

alcohol catabolic process [inference]

polyol catabolic process [inference]

inositol phosphate catabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

dephosphorylation [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

inositol phosphate metabolic process [inference]

inositol phosphate catabolic process

organophosphate catabolic process [inference]

inositol phosphate catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

lipid modification [inference]

phospholipid dephosphorylation [inference]

phosphatidylinositol dephosphorylation

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process [inference]

phosphatidylinositol dephosphorylation

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
axon terminus	ISO
membrane	IBA
presynapse	IBA IEA ISO
ruffle membrane	ISO
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

ruffle membrane

membrane microdomain [inference]

membrane raft

leading edge membrane [inference]

ruffle membrane

cell projection

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton

neuron projection terminus [inference]

axon terminus

perinuclear region of cytoplasm

axon terminus

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule [inference]

cytoplasmic microtubule

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
SH3 domain binding	ISO
phosphatidylinositol monophosphate phosphatase activity	ISO
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA IDA	9442075
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	ISO
PDZ domain binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

phosphoric ester hydrolase activity [inference]

phosphatase activity [inference]

inositol phosphate phosphatase activity [inference]

inositol trisphosphate phosphatase activity [inference]

inositol-1,4,5-trisphosphate 5-phosphatase activity

inositol tetrakisphosphate phosphatase activity [inference]

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity

phosphatidylinositol phosphate phosphatase activity [inference]

phosphatidylinositol bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol phosphate 5-phosphatase activity [inference]

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

phosphatidylinositol monophosphate phosphatase activity

binding [inference]

protein binding [inference]

protein domain specific binding [inference]

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

synaptojanin-2 isoform a

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription

Displaying **all 3** entries
Gene Ontology
SH3 domain binding
lipid metabolic process
phosphatidylinositol phosphate phosphatase activity

Displaying **all 9** entries
InterPro
Endonuclease/exonuclease/phosphatase superfamily
Inositol 5-phosphatase
Inositol polyphosphate-related phosphatase
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily
SAC domain
Synaptojanin-1/2, RNA recognition motif
Synaptojanin-2, RNA recognition motif

Rhea

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

phosphate + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)

Enzyme

3.1.3.36

PMID

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0060894	early-onset Parkinson's disease	Alliance of Genome Resources
DOID:14250	Down syndrome	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001398
Gene Name: synaptojanin 2

Ortholog

Displaying entries **91 - 97** of 97 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Acomys russatus	127204921	60746_0:003714
Phodopus roborovskii	127237741	109678_0:0046f9
Apodemus sylvaticus	127673547	10129_0:0052ac
Peromyscus californicus insignis	128118343	564181_0:0022e2
Psammomys obesus	129683299	48139_1:002826
Chionomys nivalis	130861846	269649_0:0008c8
Peromyscus eremicus	131918627	42410_0:0030f9

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.0

Last updated: December 9, 2024