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MTSS I-BAR domain containing 1

Summary

Gene Symbol

Mtss1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

211401

PubChem

211401

Alliance of Genome Resources

MGI:2384818

Annotation

Keyword

3D-structure
Actin-binding
Alternative splicing
Coiled coil
Cytoskeleton
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
G3X9H7
Q6ZQB7
Q8R1S4	Metastasis suppressor protein 1 Missing in metastasis protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 19 in total

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GO Term	Evidence Code	PMID
in utero embryonic development	IGI	21406566
plasma membrane organization	IEA
actin filament organization	IDA	12482861
nervous system development	NAS	12482861
muscle organ development	NAS	12482861

GO Hierarchy

biological process

cellular process [inference]

cell population proliferation [inference]

epithelial cell proliferation [inference]

epithelial cell proliferation involved in renal tubule morphogenesis

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

nephron tubule epithelial cell differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

nephron tubule epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to fluid shear stress

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

cell junction organization [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

cell-cell junction organization [inference]

adherens junction organization [inference]

adherens junction maintenance

cell-cell junction maintenance [inference]

adherens junction maintenance

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein polymerization [inference]

actin filament polymerization

cellular component maintenance [inference]

cell junction maintenance [inference]

cell-cell junction maintenance [inference]

adherens junction maintenance

membrane organization [inference]

plasma membrane organization

supramolecular fiber organization [inference]

actin filament organization

actin polymerization or depolymerization [inference]

actin filament polymerization

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis

glomerulus morphogenesis

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

epithelium development [inference]

kidney epithelium development [inference]

metanephric epithelium development [inference]

metanephric tubule development

tube development [inference]

metanephric tubule development

animal organ development [inference]

muscle organ development

system development [inference]

nervous system development

muscle structure development [inference]

muscle organ development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

epithelial cell differentiation involved in kidney development [inference]

nephron tubule epithelial cell differentiation

cell differentiation involved in kidney development [inference]

epithelial cell differentiation involved in kidney development [inference]

nephron tubule epithelial cell differentiation

homeostatic process [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

magnesium ion homeostasis

inorganic ion homeostasis [inference]

magnesium ion homeostasis

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to fluid shear stress

response to fluid shear stress [inference]

cellular response to fluid shear stress

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to fluid shear stress

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular process [inference]

regulation of actin filament-based process [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular component biogenesis [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular process [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of epithelial cell proliferation

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

regulation of cytoskeleton organization [inference]

regulation of actin cytoskeleton organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of cytoskeleton organization [inference]

positive regulation of actin filament bundle assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly

regulation of supramolecular fiber organization [inference]

regulation of actin filament organization [inference]

regulation of actin filament bundle assembly [inference]

positive regulation of actin filament bundle assembly

positive regulation of supramolecular fiber organization [inference]

positive regulation of actin filament bundle assembly

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	12482861
adherens junction	IDA	21406566
cytoplasmic side of plasma membrane	IBA
actin cytoskeleton	ISS
actin cytoskeleton	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

side of membrane [inference]

cytoplasmic side of membrane [inference]

cytoplasmic side of plasma membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
actin binding	IDA	12482861
actin binding	IBA
actin monomer binding	ISS
actin monomer binding	ISO
signaling receptor binding	ISS

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

cytoskeletal protein binding [inference]

actin binding

identical protein binding

lipid binding [inference]

phospholipid binding

protein-containing complex binding [inference]

actin filament binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protein MTSS 1 isoform 1

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
actin binding
cell projection assembly
phospholipid binding
plasma membrane organization

Displaying **all 3** entries
InterPro
AH/BAR domain superfamily
I-BAR domain containing protein MTSS1/MTSS2
IMD/I-BAR domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060060	non-Hodgkin lymphoma	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9788	Xenbase:XB-GENE-1013322	HUMAN95429
Drosophila melanogaster	92154	FB:FBgn0053558
Xenopus tropicalis	211401	Xenbase:XB-GENE-1013322
Drosophila melanogaster	244654	FB:FBgn0053558
Rattus norvegicus	362918		RATNO39283
Pan troglodytes	464381		PANTR43241
Canis lupus familiaris	482037		CANLF03206
Bos taurus	523498		BOVIN05746
Macaca mulatta	711465		MACMU43456
Monodelphis domestica	100032197		MONDO18667