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5'-aminolevulinate synthase 1

Summary

Gene Symbol

ALAS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

211

PubChem

211

Alliance of Genome Resources

HGNC:396

Annotation

Keyword

Acyltransferase
Alternative splicing
Heme biosynthesis
Hydroxylation
Membrane
Mitochondrion
Mitochondrion inner membrane
Pyridoxal phosphate
Reference proteome
Transit peptide
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B4DVA0	5-aminolevulinic acid synthase 1 Delta-ALA synthase 1 Delta-aminolevulinate synthase 1
P13196	5-aminolevulinic acid synthase 1 Delta-ALA synthase 1 Delta-aminolevulinate synthase 1
Q5JAM2	5-aminolevulinic acid synthase Delta-ALA synthase Delta-aminolevulinate synthase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protoporphyrinogen IX biosynthetic process	IEA
heme biosynthetic process	IBA
heme A biosynthetic process	IEA
heme B biosynthetic process	IEA
hemoglobin biosynthetic process	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process [inference]

hemoglobin biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

hemoglobin biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

hemoglobin biosynthetic process

pigment metabolic process [inference]

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

pigment biosynthetic process [inference]

heme biosynthetic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process [inference]

hemoglobin biosynthetic process

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

protein metabolic process [inference]

hemoglobin metabolic process [inference]

hemoglobin biosynthetic process

organic cyclic compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

hemoglobin metabolic process [inference]

hemoglobin biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

hemoglobin biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

organic cyclic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

organonitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

hemoglobin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

hemoglobin biosynthetic process

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

aromatic compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular nitrogen compound biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heterocycle metabolic process [inference]

heterocycle biosynthetic process [inference]

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

tetrapyrrole metabolic process [inference]

porphyrin-containing compound metabolic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

heme metabolic process [inference]

heme biosynthetic process

heme a metabolic process [inference]

heme A biosynthetic process

heme B metabolic process [inference]

heme B biosynthetic process

heme O metabolic process [inference]

heme O biosynthetic process

protoporphyrinogen IX metabolic process [inference]

protoporphyrinogen IX biosynthetic process

tetrapyrrole biosynthetic process [inference]

porphyrin-containing compound biosynthetic process [inference]

protoporphyrinogen IX biosynthetic process

heme biosynthetic process

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

cellular developmental process [inference]

cell development [inference]

hemopoiesis [inference]

myeloid cell development [inference]

erythrocyte development

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to organic cyclic compound [inference]

response to bile acid

response to lipid [inference]

response to bile acid

response to oxygen-containing compound [inference]

response to bile acid

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
mitochondrion	IDA
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial inner membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 5** entries
GO Term	Evidence Code	PMID
5-aminolevulinate synthase activity	IDA	16234850 17975826
5-aminolevulinate synthase activity	IBA
protein binding	IPI	21516116 25416956 25910212 28514442 31515488 32296183 32814053 33961781
pyridoxal phosphate binding	IEA
identical protein binding	IPI	25416956 32296183

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

N-acyltransferase activity [inference]

N-succinyltransferase activity [inference]

5-aminolevulinate synthase activity

succinyltransferase activity [inference]

N-succinyltransferase activity [inference]

5-aminolevulinate synthase activity

binding [inference]

protein binding

identical protein binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

organic cyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

5-aminolevulinate synthase

Functional Category

K: Transcription
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
5-aminolevulinate synthase activity
erythrocyte development
heme biosynthetic process
hemoglobin biosynthetic process
porphyrin-containing compound metabolic process
protoporphyrinogen IX biosynthetic process
pyridoxal phosphate binding
tetrapyrrole biosynthetic process
transferase activity

Displaying **all 7** entries
InterPro
5-aminolevulinate synthase presequence
Aminotransferase, class I/classII
Aminotransferase, class-II, pyridoxal-phosphate binding site
Pyridoxal phosphate-dependent transferase, major domain
Pyridoxal phosphate-dependent transferase, small domain
Pyridoxal phosphate-dependent transferase
Tetrapyrrole biosynthesis, 5-aminolevulinic acid synthase

Ortholog

Displaying entries **81 - 84** of 84 in total

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Species	Gene ID	Orthologous MAtrix
Rhinolophus ferrumequinum	117037013	RHIFE16464
Scophthalmus maximus	118309647	SCOMX27218
Balaenoptera musculus	118903846	BALMU26394
Ursus americanus	123798724	URSAM04583

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OrthoDB (Group)

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Acknowledgements