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solute carrier family 18 (vesicular monoamine), member 2

Summary

Gene Symbol

Slc18a2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

214084

PubChem

214084

Alliance of Genome Resources

MGI:106677

Annotation

Keyword

Cell projection
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Neurotransmitter transport
Phosphoprotein
Reference proteome
Synapse
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BRU6	Monoamine transporter Solute carrier family 18 member 2 Vesicular amine transporter 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
response to amphetamine	IMP	9275230
serotonin secretion by mast cell	IMP	10618388
histamine secretion by mast cell	IMP	10618388
neurotransmitter transport	ISO
locomotory behavior	IMP	9275230

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

exocytic process [inference]

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

dopamine secretion [inference]

somato-dendritic dopamine secretion

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

multicellular organismal process [inference]

behavior [inference]

locomotory behavior

post-embryonic development

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

response to toxic substance

response to organic substance [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to amine [inference]

response to amphetamine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

neurotransmitter transport

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

neurotransmitter loading into synaptic vesicle

aminergic neurotransmitter loading into synaptic vesicle

hormone transport [inference]

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

xenobiotic transport

secretion [inference]

histamine secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

dopamine secretion [inference]

somato-dendritic dopamine secretion

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

amine transport [inference]

aminergic neurotransmitter loading into synaptic vesicle

monoamine transport

serotonin transport [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

serotonin uptake

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

organic hydroxy compound transport [inference]

serotonin transport [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

serotonin uptake

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

histamine transport [inference]

histamine secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine uptake

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amine transport [inference]

aminergic neurotransmitter loading into synaptic vesicle

monoamine transport

serotonin transport [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

serotonin uptake

catecholamine transport [inference]

dopamine transport [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

histamine transport [inference]

histamine secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

histamine uptake

import into cell [inference]

neurotransmitter uptake [inference]

histamine uptake

neurotransmitter reuptake [inference]

serotonin uptake

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

serotonin secretion [inference]

serotonin secretion involved in inflammatory response [inference]

serotonin secretion by mast cell

dopamine secretion [inference]

somato-dendritic dopamine secretion

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

catecholamine secretion [inference]

dopamine secretion [inference]

somato-dendritic dopamine secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization in cell [inference]

neurotransmitter loading into synaptic vesicle

aminergic neurotransmitter loading into synaptic vesicle

neurotransmitter reuptake [inference]

serotonin uptake

somato-dendritic dopamine secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

negative regulation of transport [inference]

negative regulation of neurotransmitter transport

regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter transport

negative regulation of biological process [inference]

negative regulation of transport [inference]

negative regulation of neurotransmitter transport

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

histamine secretion involved in inflammatory response [inference]

histamine secretion by mast cell

peptide hormone secretion [inference]

insulin secretion

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
centrosome	ISO
centrosome	IEA
synaptic vesicle	ISO
axon	ISS
axon	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

dense core granule membrane [inference]

neuronal dense core vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

exocytic vesicle membrane [inference]

synaptic vesicle membrane

secretory granule membrane

dense core granule membrane [inference]

neuronal dense core vesicle membrane

cell junction [inference]

synapse [inference]

dopaminergic synapse

cell projection

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

neuronal dense core vesicle

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

neuronal dense core vesicle

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

secretory granule [inference]

dense core granule

neuronal dense core vesicle

exocytic vesicle [inference]

synaptic vesicle

cell body

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynapse [inference]

postsynapse

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
amine transmembrane transporter activity	ISO
serotonin:sodium:chloride symporter activity	IBA
protein binding	IPI	19357284
monoamine:proton antiporter activity	ISO
monoamine:proton antiporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

amine transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

monoamine:proton antiporter activity

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoatomic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoamine:proton antiporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

monoamine:proton antiporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

active transmembrane transporter activity [inference]

monoamine transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

antiporter activity [inference]

monoamine:proton antiporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

monoatomic anion:monoatomic cation symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

monoamine:proton antiporter activity

xenobiotic transmembrane transporter activity

organic hydroxy compound transmembrane transporter activity [inference]

serotonin:sodium:chloride symporter activity

salt transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

monoatomic anion:sodium symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

chloride transmembrane transporter activity [inference]

chloride:monoatomic cation symporter activity [inference]

sodium:chloride symporter activity [inference]

serotonin:sodium:chloride symporter activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
MFS transporter superfamily
Major facilitator superfamily domain
Major facilitator superfamily

Ortholog

Displaying entries **1 - 10** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	6570	FB:FBgn0260964
Homo sapiens	6571	ZFIN:ZDB-GENE-080514-1	HUMAN03115
Rattus norvegicus	25549	ZFIN:ZDB-GENE-080514-1	RATNO20740
Drosophila melanogaster	25693	FB:FBgn0260964
Drosophila melanogaster	110877	FB:FBgn0260964
Danio rerio	180837	ZFIN:ZDB-GENE-080514-1
Danio rerio	214084	ZFIN:ZDB-GENE-080514-1
Bos taurus	282471		BOVIN21633
Pan troglodytes	466213		PANTR01638
Canis lupus familiaris	486908		CANLF11511

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Acknowledgements