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Guidelines

MIRAGE

treacle ribosome biogenesis factor 1

Summary

Gene Symbol

Tcof1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

21453

PubChem

21453

Alliance of Genome Resources

MGI:892003

Annotation

Keyword

Acetylation
Isopeptide bond
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q6PFZ6
H3BL37
O08784	Treacher Collins syndrome protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
regulation of translation	ISS
regulation of translation	ISO
neural crest formation	ISS
neural crest formation	ISO
neural crest cell development	ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA metabolic process [inference]

rRNA metabolic process [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase I [inference]

nucleolar large rRNA transcription by RNA polymerase I

ncRNA transcription [inference]

rRNA transcription [inference]

nucleolar large rRNA transcription by RNA polymerase I

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

neural crest formation

cell development [inference]

stem cell development [inference]

neural crest cell development

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

neural crest formation

anatomical structure development [inference]

cell development [inference]

stem cell development [inference]

neural crest cell development

cellular developmental process [inference]

cell differentiation [inference]

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

neural crest formation

cell development [inference]

stem cell development [inference]

neural crest cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
fibrillar center	ISO
nucleoplasm	ISO
nucleolus	ISO
nucleolus	IBA
cytosol	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein heterodimerization activity	ISO
scaffold protein binding	ISO
scaffold protein binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

protein dimerization activity [inference]

protein heterodimerization activity

scaffold protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Treacle protein

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
nucleolar large rRNA transcription by RNA polymerase I
scaffold protein binding

Displaying **all 3** entries
InterPro
LIS1 homology motif
Treacle protein domain
Treacle protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2908	Treacher Collins syndrome	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 36 in total

« First

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ovis aries	101110509		SHEEP16931
Gorilla gorilla gorilla	101137573		GORGO33726
Ictidomys tridecemlineatus	101962756		ICTTR07452
Chinchilla lanigera	102015715		CHILA04735
Macaca fascicularis	102128194		MACFA36713
Capra hircus	102174025		CAPHI27172
Chlorocebus sabaeus	103244794		CHLSB11113
Rhinopithecus roxellana	104670413		RHIRO28089
Macaca nemestrina	105466868		MACNE08030
Mandrillus leucophaeus	105543429		MANLE16378

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Last updated: December 8, 2025