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aldhehyde dehydrogenase family 5, subfamily A1

Summary

Gene Symbol

Aldh5a1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

214579

PubChem

214579

Alliance of Genome Resources

MGI:2441982

Annotation

Keyword

Acetylation
Direct protein sequencing
Disulfide bond
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B2RS41
Q8BWF0	Aldehyde dehydrogenase family 5 member A1 NAD(+)-dependent succinic semialdehyde dehydrogenase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
synaptic transmission, GABAergic	IMP	11544478 15262267
succinate metabolic process	IMP ISO ISS	12065715
gamma-aminobutyric acid catabolic process	IBA IEA IMP ISO ISS	11544478 15262267
post-embryonic development	IMP	12065715
central nervous system development	ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

glutamate metabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

catabolic process [inference]

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

small molecule catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organic substance catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

organonitrogen compound catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

alpha-amino acid metabolic process [inference]

glutamine family amino acid metabolic process [inference]

glutamate metabolic process

monocarboxylic acid metabolic process [inference]

gamma-aminobutyric acid metabolic process

gamma-aminobutyric acid catabolic process

dicarboxylic acid metabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

cellular catabolic process [inference]

organic acid catabolic process [inference]

carboxylic acid catabolic process [inference]

amino acid catabolic process [inference]

gamma-aminobutyric acid catabolic process

multicellular organismal process [inference]

post-embryonic development

developmental process [inference]

anatomical structure development [inference]

system development [inference]

central nervous system development

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, GABAergic

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion	HDA IBA IDA ISO	14651853 18614015
synapse	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
carboxylic acid binding	ISO
NAD binding	ISO
identical protein binding	IEA ISO
succinate-semialdehyde dehydrogenase (NAD+) activity	IBA ISO ISS

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

succinate-semialdehyde dehydrogenase [NAD(P)+] activity [inference]

succinate-semialdehyde dehydrogenase (NAD+) activity

binding [inference]

protein binding [inference]

identical protein binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

succinate-semialdehyde dehydrogenase, mitochondrial

Functional Category

C: Energy production and conversion
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
gamma-aminobutyric acid catabolic process
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
oxidoreductase activity
succinate-semialdehyde dehydrogenase [NAD(P)+] activity

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060175	succinic semialdehyde dehydrogenase deficiency	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **108** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7915		HGNC:408	HUMAN83303
Rattus norvegicus	29505		RGD:621422
Drosophila melanogaster	43092		FB:FBgn0039349
Caenorhabditis elegans	174991		WB:WBGene00000113
Rattus norvegicus	291133	10116_1:004c6f
Pan troglodytes	449515			PANTR37348
Bos taurus	532724			BOVIN19101
Danio rerio	565235		ZFIN:ZDB-GENE-070228-2	DANRE10688
Macaca mulatta	707902			MACMU35697
Saccharomyces cerevisiae S288C	852291		SGD:S000000210