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CTF18, chromosome transmission fidelity factor 18

Summary

Gene Symbol

Chtf18

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

214901

PubChem

214901

Alliance of Genome Resources

MGI:2384887

Annotation

Keyword

ATP-binding
Cell cycle
DNA replication
DNA-binding
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
E9PVJ3
A0A0R4J0I4
Q8BIW9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 9** of 9 in total

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GO Term	Evidence Code	PMID
DNA duplex unwinding
negative regulation of chromosome segregation	IMP	23133398
positive regulation of DNA-directed DNA polymerase activity	ISS
positive regulation of DNA-directed DNA polymerase activity	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular process [inference]

cell cycle process [inference]

chromosome segregation

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiotic nuclear division [inference]

male meiotic nuclear division

cellular process involved in reproduction in multicellular organism [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA recombination [inference]

homologous recombination [inference]

reciprocal homologous recombination [inference]

reciprocal meiotic recombination

cellular developmental process [inference]

cell development [inference]

germ cell development

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

organelle fission [inference]

nuclear division [inference]

meiotic nuclear division [inference]

male meiotic nuclear division

chromosome organization [inference]

DNA conformation change [inference]

DNA geometric change [inference]

DNA duplex unwinding

reproductive process [inference]

developmental process involved in reproduction [inference]

germ cell development

cellular process involved in reproduction in multicellular organism [inference]

meiotic cell cycle process [inference]

reciprocal meiotic recombination

meiotic nuclear division [inference]

male meiotic nuclear division

developmental process [inference]

developmental process involved in reproduction [inference]

germ cell development

anatomical structure development [inference]

cell development [inference]

germ cell development

cellular developmental process [inference]

cell development [inference]

germ cell development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of chromosome segregation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA metabolic process [inference]

regulation of DNA replication [inference]

regulation of DNA-templated DNA replication [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA biosynthetic process [inference]

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

positive regulation of nucleobase-containing compound metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA biosynthetic process [inference]

positive regulation of DNA-directed DNA polymerase activity

negative regulation of cellular process [inference]

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of chromosome segregation

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

negative regulation of cell cycle process [inference]

negative regulation of chromosome segregation

regulation of chromosome segregation [inference]

negative regulation of chromosome segregation

negative regulation of cell cycle [inference]

negative regulation of cell cycle process [inference]

negative regulation of chromosome segregation

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of transferase activity [inference]

positive regulation of transferase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

regulation of DNA-directed DNA polymerase activity [inference]

positive regulation of DNA-directed DNA polymerase activity

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
male germ cell nucleus	IDA	18250106
nucleus	IDA	18250106
nucleus	IBA
nucleoplasm	ISO
cytoplasm	IDA	18250106

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

Ctf18 RFC-like complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

germ cell nucleus [inference]

male germ cell nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

germ cell nucleus [inference]

male germ cell nucleus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
DNA binding	IBA
DNA binding	IEA
DNA clamp loader activity	ISS
DNA clamp loader activity	ISO
DNA clamp loader activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

DNA clamp loader activity

binding [inference]

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity [inference]

single-stranded DNA helicase activity

DNA clamp loader activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

chromosome transmission fidelity protein 18

Functional Category

L: Replication, recombination and repair
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
ATP binding

Displaying **all 3** entries
InterPro
AAA+ ATPase domain
ATPase, AAA-type, core
P-loop containing nucleoside triphosphate hydrolase

Ortholog

Displaying entries **1 - 10** of 49 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	63922	Xenbase:XB-GENE-987602	HUMAN25586
Xenopus tropicalis	214901	Xenbase:XB-GENE-987602
Rattus norvegicus	287146		RATNO01749
Bos taurus	517007		BOVIN19972
Danio rerio	554366		DANRE18328
Macaca mulatta	698475		MACMU27752
Monodelphis domestica	100021342		MONDO29978
Equus caballus	100067225		HORSE07033
Ornithorhynchus anatinus	100085231		ORNAN14749
Sus scrofa	100520370		PIGXX21236

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

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Acknowledgements