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Guidelines

MIRAGE

coagulation factor VIII

Summary

Gene Symbol

F8

Organism

Homo sapiens (human)

External Links

NCBI Gene

2157

PubChem

2157

Alliance of Genome Resources

HGNC:3546

Annotation

Keyword

3D-structure
Acute phase
Alternative splicing
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hemophilia
Metal-binding
Pharmaceutical
Reference proteome
Repeat
Secreted
Signal
Sulfation
Thrombophilia

Proteins

Displaying 1 entry
UniProt	Protein Name
P00451	Antihemophilic factor Procoagulant component

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
blood coagulation	TAS	8275087
blood coagulation, intrinsic pathway	IBA
acute-phase response	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

Displaying entries **1 - 5** of 8 in total

1

2

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Last »
GO Term	Evidence Code	PMID
COPII-coated ER to Golgi transport vesicle	TAS
plasma membrane	TAS
extracellular space	IBA
extracellular region	NAS TAS	14718574
Golgi lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

endoplasmic reticulum-Golgi intermediate compartment membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein binding	IPI	18492805 26157780 27749002 32814053 7756647 8562925
copper ion binding	IEA
oxidoreductase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0060574	von Willebrand's disease 2	Alliance of Genome Resources
DOID:12134	factor VIII deficiency	Alliance of Genome Resources
DOID:801	hemarthrosis	Alliance of Genome Resources
DOID:9279	hyperhomocysteinemia	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.1.1

Last updated: February 17, 2025