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Guidelines

MIRAGE

coagulation factor VIII

Summary

Gene Symbol

F8

Organism

Homo sapiens (human)

External Links

NCBI Gene

2157

PubChem

2157

Alliance of Genome Resources

HGNC:3546

Annotation

Keyword

3D-structure
Acute phase
Alternative splicing
Calcium
Direct protein sequencing
Disease variant
Disulfide bond
Glycoprotein
Hemophilia
Metal-binding
Pharmaceutical
Reference proteome
Repeat
Secreted
Signal
Sulfation
Thrombophilia

Proteins

Displaying 1 entry
UniProt	Protein Name
P00451	Antihemophilic factor Procoagulant component

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
acute-phase response	IEA
blood coagulation	TAS	8275087
blood coagulation, intrinsic pathway	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

primary metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

protein activation cascade [inference]

blood coagulation, intrinsic pathway

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

acute inflammatory response [inference]

acute-phase response

biological regulation [inference]

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular region	NAS	14718574
extracellular region	TAS
extracellular space	IBA
endoplasmic reticulum lumen	TAS
Golgi lumen	TAS

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

endoplasmic reticulum-Golgi intermediate compartment membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

vesicle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

intracellular organelle lumen [inference]

cytoplasmic vesicle lumen [inference]

secretory granule lumen [inference]

platelet alpha granule lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

COPII-coated ER to Golgi transport vesicle

Displaying **all 3** entries
GO Term	Evidence Code	PMID
copper ion binding	IEA
protein binding	IPI	18492805 26157780 27749002 32814053 7756647 8562925
oxidoreductase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

coagulation factor VIII

Functional Category

G: Carbohydrate transport and metabolism
P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
copper ion binding
oxidoreductase activity

Displaying **all 7** entries
InterPro
Coagulation factor 5/8 C-terminal domain
Coagulation factor 5/8-like
Cupredoxin
Galactose-binding-like domain superfamily
Multicopper oxidase, C-terminal
Multicopper oxidase-like, N-terminal
Multicopper oxidases, conserved site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12134	factor VIII deficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2157	Xenbase:XB-GENE-1019544
Mus musculus	14069	Xenbase:XB-GENE-1019544	MOUSE65911
Rattus norvegicus	302470		RATNO14121
Sus scrofa	397339		PIGXX38320
Canis lupus familiaris	403875		CANLF20329
Takifugu rubripes	445944		TAKRU10920
Equus caballus	100063026		HORSE44391
Ornithorhynchus anatinus	100084142		ORNAN23127
Pongo abelii	100174452		PONAB37286
Taeniopygia guttata	100223378		TAEGU22681

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025