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solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8

Summary

Gene Symbol

Slc17a8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

216227

PubChem

216227

Alliance of Genome Resources

MGI:3039629

Annotation

Keyword

Cell membrane
Chloride channel
Cytoplasmic vesicle
Deafness
Glycoprotein
Hearing
Neurotransmitter transport
Phosphate transport
Proteomics identification
Reference proteome
Sodium transport
Symport
Synaptosome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
D3YTT3
Q3UE85
Q8BFU8	Solute carrier family 17 member 8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
regulation of acetylcholine uptake	IMP ISO ISS	18278042
regulation of synapse structure or activity	IBA
neurotransmitter loading into synaptic vesicle	IBA IEA ISO
positive regulation of glutamate uptake involved in transmission of nerve impulse	IMP	18215623
cochlea development	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure development [inference]

homeostatic process [inference]

chemical homeostasis [inference]

inorganic ion homeostasis [inference]

phosphate ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transport

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

neurotransmitter transport [inference]

neurotransmitter loading into synaptic vesicle

inorganic anion transport [inference]

phosphate ion transport [inference]

sodium-dependent phosphate transport

chloride transport [inference]

chloride transmembrane transport

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

nitrogen compound transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

acidic amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-amino acid transport [inference]

L-glutamate import

L-glutamate transmembrane transport

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

amide transport [inference]

L-glutamate import

L-glutamate transmembrane transport

establishment of localization in cell [inference]

neurotransmitter loading into synaptic vesicle

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

synaptic transmission, glutamatergic

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transport [inference]

regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamate import across plasma membrane [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamate import across plasma membrane [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter uptake [inference]

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter uptake [inference]

positive regulation of neurotransmitter uptake [inference]

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter uptake [inference]

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amine transport [inference]

regulation of acetylcholine uptake

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transport [inference]

regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamate import across plasma membrane [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of neurotransmitter transport [inference]

positive regulation of neurotransmitter uptake [inference]

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of amino acid uptake involved in synaptic transmission [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of amino acid transmembrane transport [inference]

regulation of amino acid import across plasma membrane [inference]

regulation of L-glutamate import across plasma membrane [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of glutamate uptake involved in transmission of nerve impulse [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of L-glutamate import across plasma membrane [inference]

positive regulation of glutamate uptake involved in transmission of nerve impulse

regulation of biological quality [inference]

regulation of synapse structure or activity

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
glutamatergic synapse	IDA	32306148
synaptic vesicle	IDA	27458190
excitatory synapse	IBA IEA ISO
clathrin-sculpted glutamate transport vesicle membrane	TAS
dendrite	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

chloride channel complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

exocytic vesicle membrane [inference]

synaptic vesicle membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-sculpted glutamate transport vesicle membrane

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

glial cell projection [inference]

astrocyte projection [inference]

astrocyte end-foot [inference]

glial limiting end-foot

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome [inference]

multivesicular body

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

presynapse [inference]

axon terminus

pericellular basket

Displaying **all 5** entries
GO Term	Evidence Code	PMID
chloride channel activity	ISO ISS
L-glutamate transmembrane transporter activity	IBA
neurotransmitter transmembrane transporter activity	IBA
sodium:phosphate symporter activity	ISO ISS
L-glutamate uniporter activity	IDA ISO ISS	12384506 18080752

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

neurotransmitter transmembrane transporter activity

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-glutamate uniporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-glutamate uniporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

amino acid transmembrane transporter activity [inference]

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-glutamate uniporter activity

L-amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-glutamate uniporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

chloride transmembrane transporter activity [inference]

chloride channel activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic anion transmembrane transporter activity [inference]

chloride transmembrane transporter activity [inference]

chloride channel activity

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic anion channel activity [inference]

chloride channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

uniporter activity [inference]

membrane potential driven uniporter activity [inference]

L-glutamate uniporter activity

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

active monoatomic ion transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

amide transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-glutamate uniporter activity

salt transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

L-glutamate uniporter activity

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

sodium:phosphate symporter activity

chloride transmembrane transporter activity [inference]

chloride channel activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0080855	Parkinsonism	Alliance of Genome Resources
DOID:0110555	autosomal dominant nonsyndromic deafness 25	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:1289	neurodegenerative disease	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:224	transient cerebral ischemia	Alliance of Genome Resources
DOID:5463	cochlear disease	Alliance of Genome Resources
DOID:9784	trichinosis	Alliance of Genome Resources

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