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MIRAGE
transforming growth factor, beta receptor II
Summary
- Gene Symbol
-
- Tgfbr2
- Organism
- Mus musculus (house mouse)
Annotation
- Keyword
-
- ATP-binding
- Alternative splicing
- Apoptosis
- Cell membrane
- Differentiation
- Disulfide bond
- Glycoprotein
- Growth regulation
- Magnesium
- Manganese
- Metal-binding
- Phosphoprotein
- Receptor
- Reference proteome
- Serine/threonine-protein kinase
- Signal
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| Q543C0 |
|
| Q8BQS9 |
|
| Q3UG22 |
|
| Q62312 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| branching involved in blood vessel morphogenesis | ||
| vasculogenesis | ||
| in utero embryonic development | ||
| epithelial to mesenchymal transition | ||
| epithelial to mesenchymal transition |
GO Hierarchy
biological process
cellular process [inference]
developmental process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of tolerance induction [inference]
positive regulation of immune system process [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
regulation of metabolic process [inference]
regulation of signaling [inference]
regulation of growth [inference]
positive regulation of biological process [inference]
positive regulation of immune system process [inference]
positive regulation of cellular process [inference]
positive regulation of multicellular organismal process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
regulation of cell communication [inference]
regulation of cell adhesion [inference]
regulation of cell population proliferation
regulation of cell differentiation [inference]
positive regulation of cellular process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
regulation of multicellular organismal process [inference]
regulation of cell activation [inference]
regulation of leukocyte activation [inference]
positive regulation of leukocyte activation [inference]
regulation of lymphocyte activation [inference]
positive regulation of cell activation [inference]
positive regulation of multicellular organismal process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| extracellular space | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| transmembrane receptor protein serine/threonine kinase activity | ||
| transforming growth factor beta receptor activity | ||
| transforming growth factor beta receptor activity | ||
| transforming growth factor beta receptor activity | ||
| transforming growth factor beta receptor activity, type I |
GO Hierarchy
- molecular adaptor activity
molecular function
catalytic activity [inference]
transferase activity [inference]
transferase activity, transferring phosphorus-containing groups [inference]
catalytic activity, acting on a protein [inference]
binding [inference]
molecular transducer activity [inference]
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- protein kinase
- Functional Category
-
- E: Amino acid transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| InterPro |
|---|
| Protein kinase domain |
| Protein kinase-like domain superfamily |
| Ser/Thr protein kinase, TGFB receptor |
| Serine/threonine-protein kinase, active site |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050466 | Loeys-Dietz syndrome | |
| DOID:0110214 | cleft soft palate | |
| DOID:10283 | prostate cancer | |
| DOID:11198 | DiGeorge syndrome |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 92 | WB:WBGene00000900 | ||
| 93 | WB:WBGene00000900 | ||
| 7048 | Xenbase:XB-GENE-485606 | HUMAN69005 | |
| 11480 | WB:WBGene00000900 | ||
| 11481 | WB:WBGene00000900 | ||
| 21813 | Xenbase:XB-GENE-485606 | ||
| 25366 | WB:WBGene00000900 | ||
| 29263 | WB:WBGene00000900 | ||
| 30739 | DANRE10303 | ||
| 81810 | Xenbase:XB-GENE-485606 | RATNO41472 |
