acyl-CoA synthetase long chain family member 4

Summary
Gene Symbol
  • ACSL4
Aliases
  • ACS4
  • LACS4
  • lignoceroyl-CoA synthase
  • long-chain fatty-acid-Coenzyme A ligase 4
Organism
Homo sapiens (human)
External Links
NCBI Gene
2182
HGNC
3571
KEGG Gene ID
hsa:2182
PubChem
2182
Alliance of Genome Resources
Annotation
Keyword
  • ATP-binding
  • Alport syndrome
  • Alternative splicing
  • Cell membrane
  • Deafness
  • Disease variant
  • Elliptocytosis
  • Fatty acid metabolism
  • Intellectual disability
  • Ligase
  • Magnesium
  • Microsome
  • Mitochondrion outer membrane
  • Nucleotide-binding
  • Peroxisome
  • Phosphoprotein
  • Reference proteome
  • Signal-anchor
  • Transmembrane helix
Proteins
Displaying all 2 entries
UniProt Protein Name
O60488
  • Arachidonate--CoA ligase
  • Long-chain acyl-CoA synthetase 4
Q8TAF6
Gene Ontology (GO)
GO Hierarchy
GO Hierarchy
Human Protein Atlas
ENSG00000068366

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K01897
Name
long-chain acyl-CoA synthetase [EC:6.2.1.3]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 96 in total
DO ID Disease Name Source
DOID:0040085 bacterial sepsis
DOID:0050776 non-syndromic X-linked intellectual disability
DOID:0060823 syndromic X-linked intellectual disability 94
DOID:0080199 colorectal carcinoma
DOID:0112050 non-syndromic X-linked intellectual disability 63
DOID:10003 sensorineural hearing loss
DOID:10283 prostate cancer
DOID:10286 prostate carcinoma
DOID:10534 stomach cancer
DOID:1059 intellectual disability
The Human Phenotype Ontology
Displaying entries 21 - 30 of 30 in total
HPO ID HPO Term
HP:0001643 Patent ductus arteriosus
HP:0001646 Abnormal aortic valve morphology
HP:0002907 Microscopic hematuria
HP:0004445 Elliptocytosis
HP:0005280 Depressed nasal bridge
HP:0010864 Intellectual disability, severe
HP:0011069 Supernumerary tooth
HP:0011463 Childhood onset
HP:0012471 Thick vermilion border
HP:0100820 Glomerulopathy
Displaying all 2 entries
Disease ID Disease Name
OMIM:300387
  • intellectual disability, X-linked 63
ORPHA:86818
  • Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP002158
Gene Name
acyl-CoA synthetase long-chain family member 4

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024