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Guidelines

MIRAGE

FCH domain only 2

Summary

Gene Symbol

Fcho2

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

218503

PubChem

218503

Alliance of Genome Resources

MGI:3505790

Annotation

Keyword

Alternative splicing
Coated pit
Coiled coil
Disulfide bond
Endocytosis
Isopeptide bond
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3UQN2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
membrane invagination	IDA	20448150
clathrin coat assembly	ISS
clathrin coat assembly	ISO
clathrin coat assembly	IBA
synaptic vesicle endocytosis	ISO

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

clathrin coat assembly

membrane organization [inference]

membrane invagination

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

vesicle-mediated transport in synapse [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

establishment of localization in cell [inference]

presynaptic endocytosis [inference]

synaptic vesicle endocytosis

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
plasma membrane	IDA	20448150
plasma membrane	IBA
clathrin-coated pit	ISO
clathrin-coated pit	IDA	20448150 21762413

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

plasma membrane region [inference]

clathrin-coated pit

synaptic membrane [inference]

presynaptic endocytic zone membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle

presynapse

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
identical protein binding	IPI	17540576 21762413

GO Hierarchy

molecular function

binding [inference]

protein binding

identical protein binding

lipid binding [inference]

phospholipid binding [inference]

phosphatidylserine binding

phosphatidylinositol binding

phosphatidylinositol phosphate binding [inference]

phosphatidylinositol bisphosphate binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

ion binding [inference]

anion binding [inference]

phosphatidylinositol-4,5-bisphosphate binding

modified amino acid binding [inference]

phosphatidylserine binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

F-BAR domain

Functional Category

I: Lipid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
clathrin coat assembly
clathrin-dependent endocytosis

Displaying **all 6** entries
InterPro
AH/BAR domain superfamily
F-BAR domain only protein 2, F-BAR domain
F-BAR domain
FCH domain
Mu homology domain
Muniscin, C-terminal

Ortholog

Displaying entries **51 - 60** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Salmo salar	106562940		SALSA17037
Sinocyclocheilus grahami	107596769		SINGR11929
Ictalurus punctatus	108260057		ICTPU22950
Rhinopithecus bieti	108541184		RHIBE07059
Cyprinus carpio carpio	109051608		CYPCA15697
Crocodylus porosus	109308043		CROPO11958
Phascolarctos cinereus	110216524		PHACI12122
Pseudonaja textilis	113447770		PSETE01983
Athene cunicularia	113490352		ATHCN19907
Bos indicus x Bos taurus	113879242		BOBOX36008

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: March 31, 2025