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tumor necrosis factor (ligand) superfamily, member 12

Summary

Gene Symbol

Tnfsf12

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

21944

PubChem

21944

Alliance of Genome Resources

MGI:1196259

Annotation

Keyword

Angiogenesis
Apoptosis
Cell membrane
Cleavage on pair of basic residues
Cytokine
Developmental protein
Differentiation
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q5F2A0
O54907	TNF-related weak inducer of apoptosis

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
angiogenesis	IEA

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

cellular developmental process [inference]

cell differentiation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

cellular developmental process [inference]

cell differentiation

response to stimulus [inference]

immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of protein catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein catabolic process

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of apoptotic signaling pathway [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

regulation of extrinsic apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of apoptotic signaling pathway [inference]

positive regulation of extrinsic apoptotic signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	IEA
extracellular region	IDA	12821115
extracellular space	IBA IEA
perinuclear region of cytoplasm	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

perinuclear region of cytoplasm

Displaying **all 3** entries
GO Term	Evidence Code	PMID
tumor necrosis factor receptor binding	IEA
receptor ligand activity	IBA
cytokine activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

tumor necrosis factor receptor superfamily binding [inference]

tumor necrosis factor receptor binding

receptor ligand activity

cytokine activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

tumor necrosis factor ligand superfamily member 12

Functional Category

I: Lipid transport and metabolism
K: Transcription
L: Replication, recombination and repair
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
Gene Ontology
immune response
positive regulation of isotype switching to IgA isotypes
tumor necrosis factor receptor binding

Displaying **all 2** entries
InterPro
Tumour necrosis factor domain
Tumour necrosis factor-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:305	carcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 67 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Rhinolophus ferrumequinum	117013812			RHIFE07697
Arvicanthis niloticus	117711663	61156_0:001cca
Onychomys torridus	118589108	38674_0:00273f
Arvicola amphibius	119811344	1047088_0:001ae6
Microtus oregoni	121457040	111838_0:00256d
Dipodomys spectabilis	122100374	105255_0:004b15
Marmota monax	124104990	9995_0:002802
Sciurus carolinensis	124979912	30640_0:00142e
Perognathus longimembris pacificus	125365459	214514_0:003cbf
Myodes glareolus	125409423	447135_0:00241f

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Last updated: December 9, 2024