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aldehyde dehydrogenase 1 family member A3

Summary

Gene Symbol

ALDH1A3

Aliases

RALDH3
retinaldehyde dehydrogenase 3

Organism

Homo sapiens (human)

External Links

NCBI Gene

220

HGNC

409

KEGG Gene ID

hsa:220

PubChem

220

Alliance of Genome Resources

HGNC:409

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Disease variant
Lipid metabolism
Microphthalmia
NAD
Oxidoreductase
Proteomics identification
Reference proteome

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P47895	Aldehyde dehydrogenase 6 Aldehyde dehydrogenase family 1 member A3
H0Y2X5
Q7Z3A2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 18 in total

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GO Term	Evidence Code	PMID
apoptotic process	IEA
positive regulation of apoptotic process	IEA
Harderian gland development	IEA
retinol metabolic process	IEA
embryonic eye morphogenesis	ISS

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

hormone metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

retinal metabolic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

retinal metabolic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

retinal metabolic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

olefinic compound metabolic process [inference]

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

retinoic acid metabolic process

retinoic acid biosynthetic process

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

cellular biosynthetic process [inference]

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

retinoic acid biosynthetic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

retinal metabolic process

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

isoprenoid biosynthetic process [inference]

terpenoid biosynthetic process [inference]

diterpenoid biosynthetic process [inference]

retinoic acid biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization [inference]

protein homotetramerization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

behavior [inference]

locomotory behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

sensory organ morphogenesis [inference]

eye morphogenesis [inference]

embryonic eye morphogenesis

embryonic morphogenesis [inference]

morphogenesis of embryonic epithelium [inference]

optic cup morphogenesis involved in camera-type eye development

inner ear morphogenesis

embryonic organ morphogenesis [inference]

embryonic eye morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of embryonic epithelium [inference]

optic cup morphogenesis involved in camera-type eye development

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development [inference]

camera-type eye development [inference]

embryonic camera-type eye development

embryonic organ development [inference]

embryonic camera-type eye development

gland development [inference]

Harderian gland development

neural nucleus development [inference]

nucleus accumbens development

response to stimulus [inference]

response to external stimulus [inference]

reflex [inference]

righting reflex

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

retinoic acid metabolic process

retinoic acid biosynthetic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol
cytoplasm	IDA	11585737
extracellular exosome	HDA	23533145

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
aldehyde dehydrogenase [NAD(P)+] activity	IDA	11585737
retinal dehydrogenase activity	IDA	27759097
protein homodimerization activity	IDA	11585737
aldehyde dehydrogenase (NAD+) activity	IBA
thyroid hormone binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

retinal dehydrogenase activity

aldehyde dehydrogenase [NAD(P)+] activity

aldehyde dehydrogenase (NAD+) activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

hormone binding [inference]

thyroid hormone binding

ion binding [inference]

anion binding [inference]

NAD+ binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

NAD binding [inference]

NAD+ binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000184254

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K07249

Name

retinal dehydrogenase [EC:1.2.1.36]

References

Rhea

RHEA:16177

retinal + H₂O + NAD⁺

retinoate + H⁺ + NADH

Enzyme

1.2.1.36

PMID

7786847

RHEA:42080

H₂O + all-trans-retinal + NAD⁺

H⁺ + all-trans-retinoate + NADH

Enzyme

1.2.1.36

PMID

Disease

Disease Ontology

Displaying entries **71 - 80** of 96 in total

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DO ID	Disease Name	Source
DOID:4928	intrahepatic cholangiocarcinoma	DisGeNET
DOID:4929	tubular adenocarcinoma	DisGeNET
DOID:4947	cholangiocarcinoma	DisGeNET
DOID:4948	gallbladder carcinoma	DisGeNET
DOID:5076	mixed glioma	DisGeNET DisGeNET
DOID:5517	stomach carcinoma	DisGeNET
DOID:5557	testicular germ cell cancer	DisGeNET
DOID:5672	large intestine cancer	DisGeNET DisGeNET
DOID:5675	cribriform carcinoma	DisGeNET
DOID:6114	cerebral convexity meningioma	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000480	Retinal coloboma
HP:0000486	Strabismus
HP:0000501	Glaucoma
HP:0000528	Anophthalmia
HP:0000541	Retinal detachment
HP:0000568	Microphthalmia
HP:0000609	Optic nerve hypoplasia
HP:0000610	Abnormal choroid morphology
HP:0000621	Entropion

Displaying **all 2** entries
Disease ID	Disease Name
OMIM:615113	isolated microphthalmia 8
ORPHA:35612	nanophthalmia

PubChem Disease

MedGen Diseases

Isolated microphthalmia 8

OMIM Phenotypes

MICROPHTHALMIA, ISOLATED 8; MCOP8

KEGG Diseases

Microphthalmia

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002047
Gene Name: aldehyde dehydrogenase 1 family, member A3

Ortholog

Displaying entries **71 - 80** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Propithecus coquereli	105808963		PROCO18928
Saccharomyces cerevisiae S288C	854556	SGD:S000005901
Saccharomyces cerevisiae S288C	855205	SGD:S000004779
Saccharomyces cerevisiae S288C	855206	SGD:S000004780
Saccharomyces cerevisiae S288C	856044	SGD:S000005982
Saccharomyces cerevisiae S288C	856804	SGD:S000000875
Cyprinus carpio carpio	109047576		CYPCA11790
Nannospalax galili	103747192		NANGA14579
Corvus moneduloides	116450248		CORMO02518
Strigops habroptila	115613124		STRHB23037

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements