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Guidelines

MIRAGE

tubulin, alpha 4A

Summary

Gene Symbol

Tuba4a

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22145

PubChem

22145

Alliance of Genome Resources

MGI:1095410

Annotation

Keyword

3D-structure
Acetylation
Cytoskeleton
Direct protein sequencing
GTP-binding
Hydrolase
Magnesium
Metal-binding
Methylation
Microtubule
Nitration
Phosphoprotein
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P68368	Alpha-tubulin 4 Alpha-tubulin isotype M-alpha-4 Tubulin alpha-4 chain

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
microtubule cytoskeleton organization	IBA
mitotic cell cycle	IBA
cytoskeleton organization	IEA
microtubule-based process	IEA

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process

microtubule cytoskeleton organization

cell cycle [inference]

mitotic cell cycle

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

microtubule cytoskeleton organization

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
cytoplasm	IEA
cytoskeleton	ISO
microtubule	ISO
microtubule	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

microtubule cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
structural constituent of cytoskeleton	IBA
structural constituent of cytoskeleton	IEA
protein binding	IPI	20405035
GTP binding	IBA
GTP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity

structural molecule activity [inference]

structural constituent of cytoskeleton

binding [inference]

protein binding

kinase binding [inference]

protein kinase binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

beta

Functional Category

D: Cell cycle control, cell division, chromosome partitioning
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
GTP binding
cytoskeleton organization
microtubule cytoskeleton organization
microtubule-based process
nucleotide binding
structural constituent of cytoskeleton

Displaying **all 8** entries
InterPro
Tubulin, C-terminal
Tubulin, conserved site
Tubulin/FtsZ, 2-layer sandwich domain
Tubulin/FtsZ, C-terminal
Tubulin/FtsZ, GTPase domain superfamily
Tubulin/FtsZ, GTPase domain
Tubulin/FtsZ-like, C-terminal domain
Tubulin

Ortholog

Displaying entries **1 - 10** of 72 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7277	Xenbase:XB-GENE-489927	HUMAN67089
Saccharomyces cerevisiae S288C	7846	SGD:S000004593
Saccharomyces cerevisiae S288C	10376	SGD:S000004593
Saccharomyces cerevisiae S288C	22142	SGD:S000004593
Saccharomyces cerevisiae S288C	22143	SGD:S000004593
Saccharomyces cerevisiae S288C	22144	SGD:S000004593
Xenopus tropicalis	22145	Xenbase:XB-GENE-489927
Saccharomyces cerevisiae S288C	22146	SGD:S000004593
Saccharomyces cerevisiae S288C	22147	SGD:S000004593
Saccharomyces cerevisiae S288C	53857	SGD:S000004593

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025