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tyrosinase-related protein 1

Summary

Gene Symbol

Tyrp1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22178

PubChem

22178

Alliance of Genome Resources

MGI:98881

Annotation

Keyword

3D-structure
Albinism
Copper
Disease variant
Disulfide bond
Glycoprotein
Melanin biosynthesis
Metal-binding
Monooxygenase
Oxidoreductase
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3UFS3	Tyrosinase-related protein 1
P07147	Brown locus protein Catalase B Tyrosinase-related protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
melanin metabolic process	IMP	9548375
melanin biosynthetic process from tyrosine	TAS	9918801
melanocyte differentiation	IMP	2379821
melanocyte differentiation	IBA
melanosome organization	IMP	9548375

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

biosynthetic process [inference]

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

secondary metabolic process [inference]

melanin metabolic process

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

pigment metabolic process [inference]

melanin metabolic process

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

pigment biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

short-chain fatty acid metabolic process [inference]

acetoacetic acid metabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

acetoacetic acid metabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound metabolic process [inference]

melanin metabolic process

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

short-chain fatty acid metabolic process [inference]

acetoacetic acid metabolic process

primary metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

short-chain fatty acid metabolic process [inference]

acetoacetic acid metabolic process

fatty acid derivative metabolic process [inference]

ketone body metabolic process [inference]

acetoacetic acid metabolic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

short-chain fatty acid metabolic process [inference]

acetoacetic acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

short-chain fatty acid metabolic process [inference]

acetoacetic acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

short-chain fatty acid metabolic process [inference]

acetoacetic acid metabolic process

fatty acid derivative metabolic process [inference]

ketone body metabolic process [inference]

acetoacetic acid metabolic process

organic cyclic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound metabolic process [inference]

melanin metabolic process

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organonitrogen compound metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

organic substance biosynthetic process [inference]

organic cyclic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic hydroxy compound metabolic process [inference]

phenol-containing compound metabolic process [inference]

melanin metabolic process

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

organic hydroxy compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

amino acid metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

alpha-amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

short-chain fatty acid metabolic process [inference]

acetoacetic acid metabolic process

generation of precursor metabolites and energy [inference]

ketone body metabolic process [inference]

acetoacetic acid metabolic process

cellular aromatic compound metabolic process [inference]

aromatic amino acid metabolic process [inference]

tyrosine metabolic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound metabolic process [inference]

melanin metabolic process

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular biosynthetic process [inference]

aromatic compound biosynthetic process [inference]

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process [inference]

melanin biosynthetic process from tyrosine

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

short-chain fatty acid metabolic process [inference]

acetoacetic acid metabolic process

cellular developmental process [inference]

cell differentiation [inference]

pigment cell differentiation [inference]

melanocyte differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

pigment granule organization [inference]

melanosome organization

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

pigment cell differentiation [inference]

melanocyte differentiation

pigmentation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of secondary metabolic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of secondary metabolite biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of cellular biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

regulation of melanin biosynthetic process [inference]

positive regulation of melanin biosynthetic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of melanin biosynthetic process

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
cytoplasm	ISO
endosome membrane	ISO
endosome membrane	IEA
clathrin-coated endocytic vesicle membrane	ISO
clathrin-coated endocytic vesicle membrane	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

endosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

pigment granule membrane [inference]

melanosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
tyrosinase activity	ISS
tyrosinase activity	ISO
protein binding	IPI	18042623 18650808 35469906 9918801
identical protein binding	IPI	9918801
protein homodimerization activity	IDA	9918801

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

tyrosinase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [inference]

tyrosinase activity

binding [inference]

protein binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

collagen

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
metal ion binding
oxidoreductase activity

Displaying **all 2** entries
InterPro
Di-copper centre-containing domain superfamily
Tyrosinase copper-binding domain

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Caenorhabditis elegans	1638	WB:WBGene00009001
Caenorhabditis elegans	7299	WB:WBGene00021553
Homo sapiens	7306	Xenbase:XB-GENE-1001464	HUMAN96439
Caenorhabditis elegans	13190	WB:WBGene00021553
Caenorhabditis elegans	22173	WB:WBGene00009001
Xenopus tropicalis	22178	Xenbase:XB-GENE-1001464
Xenopus tropicalis	176105	Xenbase:XB-GENE-1001464
Bos taurus	282105		BOVIN34328
Rattus norvegicus	298182		RATNO34066
Canis lupus familiaris	403479		CANLF02175

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements