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uracil DNA glycosylase

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22256

PubChem

22256

Alliance of Genome Resources

MGI:109352

Annotation

Keyword

Acetylation
Alternative splicing
DNA repair
Hydrolase
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q791V7
P97931

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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2

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GO Term	Evidence Code	PMID
base-excision repair	ISO
DNA repair	TAS	10871356
isotype switching	IGI	17015724
negative regulation of apoptotic process	IEA ISO
somatic recombination of immunoglobulin gene segments	IGI IMP	15494304

GO Hierarchy

biological process

immune system process [inference]

somatic diversification of immune receptors [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic diversification of immune receptors via somatic mutation [inference]

somatic hypermutation of immunoglobulin genes

somatic diversification of immunoglobulins [inference]

somatic diversification of immunoglobulins involved in immune response [inference]

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

somatic hypermutation of immunoglobulin genes

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

base-excision repair, AP site formation [inference]

base-excision repair, AP site formation via deaminated base removal

DNA recombination [inference]

somatic cell DNA recombination [inference]

somatic diversification of immune receptors via germline recombination within a single locus [inference]

somatic recombination of immunoglobulin gene segments

somatic recombination of immunoglobulin genes involved in immune response [inference]

isotype switching

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

base-excision repair

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

isotype switching

B cell activation [inference]

B cell activation involved in immune response [inference]

isotype switching

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

base-excision repair

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleoplasm	ISO TAS
mitochondrion	HDA IBA IDA ISO	10871356 14651853 18614015
nucleus	IBA IDA	10871356

GO Hierarchy

cellular component

cellular anatomical entity [inference]

nucleoplasm

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying **all 3** entries
GO Term	Evidence Code	PMID
ribosomal small subunit binding	IEA ISO
uracil DNA N-glycosylase activity	IBA IDA IMP ISO TAS	10871356 15494304
damaged DNA binding	IEA ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity [inference]

deaminated base DNA N-glycosylase activity [inference]

uracil DNA N-glycosylase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA N-glycosylase activity [inference]

deaminated base DNA N-glycosylase activity [inference]

uracil DNA N-glycosylase activity

binding [inference]

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding [inference]

ribosomal small subunit binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

uracil-DNA glycosylase

Functional Category

L: Replication, recombination and repair
T: Signal transduction mechanisms
V: Defense mechanisms

Displaying **all 6** entries
Gene Ontology
DNA repair
base-excision repair, AP site formation via deaminated base removal
base-excision repair
hydrolase activity, hydrolyzing N-glycosyl compounds
hydrolase activity
uracil DNA N-glycosylase activity

Displaying **all 4** entries
InterPro
Uracil-DNA glycosylase family 1
Uracil-DNA glycosylase, active site
Uracil-DNA glycosylase-like domain superfamily
Uracil-DNA glycosylase-like

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060759	immunodeficiency with hyper IgM type 5	Alliance of Genome Resources
DOID:11702	dysgammaglobulinemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **123** in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7374		HGNC:12572	HUMAN15265
Caenorhabditis elegans	176633		WB:WBGene00013241
Rattus norvegicus	304577	10116_1:003f36	RGD:1307200	RATNO05802
Danio rerio	393949		ZFIN:ZDB-GENE-040426-900	DANRE37165
Pan troglodytes	452217			PANTR48814
Bos taurus	511381			BOVIN09696
Bos taurus	515338			BOVIN09696
Xenopus tropicalis	549334		Xenbase:XB-GENE-960119
Danio rerio	571301		ZFIN:ZDB-GENE-070705-360
Macaca mulatta	706816			MACMU03217

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements