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potassium channel, subfamily K, member 9

Summary

Gene Symbol

Kcnk9

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

223604

PubChem

223604

Alliance of Genome Resources

MGI:3521816

Annotation

Keyword

Cell membrane
Glycoprotein
Potassium channel
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3LS21	Acid-sensitive potassium channel protein TASK-3 TWIK-related acid-sensitive K(+) channel 3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
potassium ion transport	ISO
visual perception	IMP	36070380
sodium ion transmembrane transport	IEA
regulation of resting membrane potential	IMP	30416196
cellular response to acidic pH	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

response to stimulus [inference]

response to abiotic stimulus [inference]

response to pH [inference]

response to acidic pH [inference]

cellular response to acidic pH

cellular response to pH [inference]

cellular response to acidic pH

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH [inference]

cellular response to acidic pH

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

sodium ion transport [inference]

sodium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

potassium ion import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of steroid hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of corticosteroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of mineralocorticoid secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of aldosterone secretion [inference]

negative regulation of aldosterone secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of steroid hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of corticosteroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of mineralocorticoid secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of aldosterone secretion [inference]

negative regulation of aldosterone secretion

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of steroid hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of corticosteroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of mineralocorticoid secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of aldosterone secretion [inference]

negative regulation of aldosterone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of lipid localization [inference]

regulation of lipid transport [inference]

negative regulation of lipid transport [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of steroid hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of corticosteroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of mineralocorticoid secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of aldosterone secretion [inference]

negative regulation of aldosterone secretion

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of transport [inference]

negative regulation of lipid transport [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of multicellular organismal process [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of lipid localization [inference]

negative regulation of lipid transport [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of cellular process [inference]

regulation of cell communication [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of steroid hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of corticosteroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of mineralocorticoid secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of aldosterone secretion [inference]

negative regulation of aldosterone secretion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of secretion by cell [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of steroid hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of corticosteroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of mineralocorticoid secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of aldosterone secretion [inference]

negative regulation of aldosterone secretion

negative regulation of secretion by cell [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of multicellular organismal process [inference]

regulation of system process [inference]

regulation of endocrine process [inference]

regulation of steroid hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of corticosteroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of mineralocorticoid secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of aldosterone secretion [inference]

negative regulation of aldosterone secretion

negative regulation of multicellular organismal process [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of action potential [inference]

regulation of action potential firing rate

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone secretion [inference]

negative regulation of hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of steroid hormone secretion [inference]

negative regulation of steroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of corticosteroid hormone secretion [inference]

negative regulation of corticosteroid hormone secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of mineralocorticoid secretion [inference]

negative regulation of mineralocorticoid secretion [inference]

negative regulation of aldosterone secretion

regulation of aldosterone secretion [inference]

negative regulation of aldosterone secretion

regulation of membrane potential [inference]

regulation of resting membrane potential

regulation of action potential [inference]

regulation of action potential firing rate

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
mitochondrial inner membrane	IDA	28630209
plasma membrane	ISO
plasma membrane	IDA	30416196
plasma membrane	IBA
synaptic vesicle	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
voltage-gated potassium channel activity	IDA	20351106
potassium channel activity	ISO
sodium channel activity	IEA
protein binding	IPI	30416196
outward rectifier potassium channel activity	ISS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity

voltage-gated potassium channel activity

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

narrow pore channel activity [inference]

leak channel activity [inference]

potassium ion leak channel activity

salt transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity

voltage-gated potassium channel activity

outward rectifier potassium channel activity

potassium ion leak channel activity

sodium ion transmembrane transporter activity [inference]

sodium channel activity

binding [inference]

protein binding

identical protein binding

protein dimerization activity [inference]

protein heterodimerization activity

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

potassium channel subfamily k

Functional Category

E: Amino acid transport and metabolism
K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
monoatomic ion transport
outward rectifier potassium channel activity
potassium channel activity
potassium ion leak channel activity
stabilization of membrane potential

Displaying **all 3** entries
InterPro
Potassium channel domain
Two pore domain potassium channel, TASK family
Two pore domain potassium channel

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	3777	FB:FBgn0038165
Drosophila melanogaster	16527	FB:FBgn0038165
Drosophila melanogaster	29553	FB:FBgn0038165
Homo sapiens	51305	Xenbase:XB-GENE-952039	HUMAN95650
Rattus norvegicus	84429	Xenbase:XB-GENE-952039	RATNO39440
Xenopus tropicalis	173613	Xenbase:XB-GENE-952039
Xenopus tropicalis	223604	Xenbase:XB-GENE-952039
Pan troglodytes	464416		PANTR43329
Xenopus tropicalis	494803	Xenbase:XB-GENE-952039
Monodelphis domestica	100027125		MONDO18967

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Acknowledgements