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flap structure-specific endonuclease 1

Summary

Gene Symbol

FEN1

Organism

Homo sapiens (human)

External Links

NCBI Gene

2237

PubChem

2237

Alliance of Genome Resources

HGNC:3650

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Coiled coil
DNA repair
DNA replication
Direct protein sequencing
Endonuclease
Exonuclease
Magnesium
Metal-binding
Methylation
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q6FHX6	Flap structure-specific endonuclease 1
P39748	DNase IV Flap structure-specific endonuclease 1 Maturation factor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
double-strand break repair via homologous recombination	TAS
DNA replication	TAS	9778254
DNA repair	TAS	8007985
base-excision repair, gap-filling	TAS
double-strand break repair	TAS	8131753

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

catabolic process [inference]

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

organic cyclic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular process [inference]

cell cycle process [inference]

telomere maintenance via semi-conservative replication

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular catabolic process [inference]

aromatic compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular nitrogen compound catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

nucleic acid metabolic process

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

base-excision repair, gap-filling

DNA recombination [inference]

recombinational repair [inference]

double-strand break repair via homologous recombination

RNA metabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

heterocycle catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

RNA catabolic process [inference]

DNA replication, removal of RNA primer

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via semi-conservative replication

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

behavior [inference]

learning or memory [inference]

memory

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

UV protection

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

regulation of chromosome organization [inference]

regulation of sister chromatid cohesion [inference]

positive regulation of sister chromatid cohesion

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of chromosome organization [inference]

positive regulation of sister chromatid cohesion

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of sister chromatid cohesion [inference]

positive regulation of sister chromatid cohesion

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of sister chromatid cohesion

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IDA	24270157
chromosome, telomeric region	HDA	19135898
nucleus	IDA	12427278 18995831 7961795
nucleus	IBA
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

nucleolus

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IBA
DNA binding	IMP	11986308
damaged DNA binding	TAS	8007985
double-stranded DNA binding	TAS	8131753
endonuclease activity	TAS	8131753

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

exonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

double-stranded DNA exodeoxyribonuclease activity

5'-3' exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

double-stranded DNA exodeoxyribonuclease activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

double-stranded DNA exodeoxyribonuclease activity

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

endodeoxyribonuclease activity, producing 5'-phosphomonoesters [inference]

5'-flap endonuclease activity

flap endonuclease activity

5'-flap endonuclease activity

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

double-stranded DNA exodeoxyribonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 5'-phosphomonoesters [inference]

RNA-DNA hybrid ribonuclease activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

transition metal ion binding [inference]

manganese ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endonuclease

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

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Gene Ontology
5'-3' exonuclease activity
5'-flap endonuclease activity
DNA repair
DNA replication, removal of RNA primer
base-excision repair
catalytic activity
endonuclease activity
hydrolase activity, acting on ester bonds
hydrolase activity
magnesium ion binding

Displaying **all 8** entries
InterPro
5'-3' exonuclease, C-terminal domain superfamily
Flap endonuclease 1
Helix-hairpin-helix motif, class 2
PIN-like domain superfamily
XPG conserved site
XPG, N-terminal
XPG-I domain
XPG/Rad2 endonuclease

Ortholog

Displaying entries **1 - 10** of 88 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	2237	Xenbase:XB-GENE-955518
Mus musculus	14156		MOUSE25983
Rattus norvegicus	84490		RATNO16268
Danio rerio	386707		DANRE26581
Pan troglodytes	451242		PANTR03103
Canis lupus familiaris	476063		CANLF06190
Bos taurus	616242		BOVIN23247
Macaca mulatta	722348		MACMU08995
Monodelphis domestica	100012289		MONDO01014
Equus caballus	100059838		HORSE06104

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Acknowledgements