GlyCosmos Portal

Submissions

Von Willebrand factor

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22371

PubChem

22371

Alliance of Genome Resources

MGI:98941

Annotation

Keyword

3D-structure
Alternative splicing
Blood coagulation
Cell adhesion
Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Proteomics identification
Reference proteome
Repeat
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E9QPU1
Q8CIZ8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

1

2

3

4

5

Next ›

Last »
GO Term	Evidence Code	PMID
liver development	IMP	7854452
placenta development	IMP	7854452
activation of blood coagulation via clotting cascade	IDA	30573509
inflammatory response	IDA	30573509
cell adhesion	ISS

GO Hierarchy

biological process

cellular process [inference]

cell activation [inference]

platelet activation

cell adhesion

cell-substrate adhesion

multicellular organismal process [inference]

cell activation [inference]

platelet activation

coagulation [inference]

blood coagulation

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

placenta development

gland development [inference]

liver development

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

positive regulation of hemostasis [inference]

positive regulation of blood coagulation [inference]

activation of blood coagulation via clotting cascade

Displaying entries **1 - 5** of 16 in total

1

2

3

4

Next ›

Last »
GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular space	ISO
extracellular space	IDA	30573509
extracellular space	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

external encapsulating structure [inference]

extracellular matrix

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

coated vesicle [inference]

clathrin-coated vesicle [inference]

Weibel-Palade body

secretory vesicle [inference]

secretory granule [inference]

Weibel-Palade body

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 15 in total

1

2

3

Next ›

Last »
GO Term	Evidence Code	PMID
protease binding	ISS
protease binding	ISO
integrin binding	ISS
integrin binding	ISO
extracellular matrix structural constituent	RCA	22159717 28071719

GO Hierarchy

molecular function

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding

signaling receptor binding [inference]

integrin binding

enzyme binding [inference]

protease binding

identical protein binding

cell adhesion molecule binding [inference]

integrin binding

protein-folding chaperone binding

protein-containing complex binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

von willebrand factor

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060574	von Willebrand's disease 2	Alliance of Genome Resources
DOID:12531	von Willebrand's disease	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 76 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	7450	Xenbase:XB-GENE-921798	HUMAN10590
Xenopus tropicalis	22371	Xenbase:XB-GENE-921798
Rattus norvegicus	116669		RATNO30628
Bos taurus	280958		BOVIN30485
Sus scrofa	399543		PIGXX26354
Canis lupus familiaris	399544		CANLF11162
Pan troglodytes	451773		PANTR04911
Felis catus	493760		FELCA17417
Danio rerio	570643		DANRE13497
Oryctolagus cuniculus	100009165		RABIT12299