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Guidelines

MIRAGE

eukaryotic translation initiation factor 2B, subunit 5 epsilon

Summary

Gene Symbol

Eif2b5

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

224045

PubChem

224045

Alliance of Genome Resources

MGI:2446176

Annotation

Keyword

Cytoplasm
Initiation factor
Isopeptide bond
Methylation
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8CHW4	eIF2B GDP-GTP exchange factor subunit epsilon

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 15** of 29 in total

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GO Term	Evidence Code	PMID
astrocyte development	ISS
astrocyte development	ISO
oligodendrocyte development	ISS
oligodendrocyte development	ISO
hippocampus development	IEA

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

metabolic process [inference]

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

ensheathment of neurons [inference]

axon ensheathment [inference]

myelination

cellular metabolic process [inference]

translational initiation

cytoplasmic translational initiation

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

astrocyte differentiation

cell development [inference]

glial cell development [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

reproductive process [inference]

developmental process involved in reproduction [inference]

ovarian follicle development

developmental process [inference]

developmental process involved in reproduction [inference]

ovarian follicle development

anatomical structure development [inference]

cell development [inference]

glial cell development [inference]

cellular developmental process [inference]

cell differentiation [inference]

glial cell differentiation [inference]

astrocyte differentiation

cell development [inference]

glial cell development [inference]

response to stimulus [inference]

response to stress [inference]

response to heat

cellular response to stress [inference]

response to endoplasmic reticulum stress

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

response to heat

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to chemical [inference]

response to organic substance [inference]

response to hormone [inference]

response to peptide hormone

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to peptide [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

response to peptide [inference]

response to peptide hormone

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

positive regulation of translational initiation

positive regulation of translation

positive regulation of translational initiation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

positive regulation of translational initiation

positive regulation of translation

positive regulation of translational initiation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

positive regulation of translational initiation

positive regulation of translation

positive regulation of translational initiation

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

positive regulation of translational initiation

positive regulation of translation

positive regulation of translational initiation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

positive regulation of translational initiation

positive regulation of translation

positive regulation of translational initiation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

positive regulation of translational initiation

positive regulation of translation

positive regulation of translational initiation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

positive regulation of translational initiation

positive regulation of translation

positive regulation of translational initiation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of amide metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of protein metabolic process [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

immune response-activating cell surface receptor signaling pathway [inference]

antigen receptor-mediated signaling pathway [inference]

T cell receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation [inference]

positive regulation of translational initiation

positive regulation of translation

positive regulation of translational initiation

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of translation

positive regulation of translational initiation

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	12388085
cytoplasm	ISS
cytoplasm	ISO
cytoplasm	IDA	12388085
cytosol	ISO

GO Hierarchy

cellular component

protein-containing complex [inference]

eukaryotic translation initiation factor 2B complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
translation initiation factor activity	ISS
translation initiation factor activity	ISO
translation initiation factor activity	IBA
guanyl-nucleotide exchange factor activity	ISS	27023709
guanyl-nucleotide exchange factor activity	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

translation initiation factor binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

guanyl-nucleotide exchange factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Translation initiation factor eIF-2B subunit epsilon

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
translation initiation factor binding

Displaying **all 7** entries
InterPro
Armadillo-type fold
Nucleotide-diphospho-sugar transferases
Nucleotidyl transferase domain
Translation initiation factor eIF-2B subunit epsilon, N-terminal
Translation initiation factor eIF-2B subunit epsilon, W2 domain
Trimeric LpxA-like superfamily
W2 domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060868	leukoencephalopathy with vanishing white matter	Alliance of Genome Resources

Ortholog

Displaying entries **21 - 30** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Canis lupus familiaris	100856343		CANLF13521
Otolemur garnettii	100951114		OTOGA00929
Pan paniscus	100978406		PANPA29368
Papio anubis	101008340		PAPAN25316
Saimiri boliviensis boliviensis	101044374		SAIBB11770
Felis catus	101089136		FELCA22569
Ovis aries	101108187		SHEEP01574
Gorilla gorilla gorilla	101145902		GORGO27903
Oryzias latipes	101164678		ORYLA06722
Tursiops truncatus	101322469		TURTR01974

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025