GlyCosmos Portal

Submissions

Werner syndrome RecQ like helicase

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

22427

KEGG Gene ID

PubChem

22427

Alliance of Genome Resources

MGI:109635

Annotation

Keyword

3D-structure
Chromosome
DNA repair
DNA-binding
Exonuclease
Helicase
Isomerase
Isopeptide bond
Magnesium
Metal-binding
Multifunctional enzyme
Nucleus
Phosphoprotein
Reference proteome
Ubl conjugation
Zinc

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q8BWH5
Q3TB25
O09053	Werner syndrome protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 52 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	PMID
telomere maintenance	ISO
telomere maintenance	IMP
telomere maintenance	IGI
telomere maintenance	IBA
telomere maintenance	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process

telomere maintenance

telomeric loop disassembly [inference]

telomeric D-loop disassembly

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process

telomere maintenance

telomeric loop disassembly [inference]

telomeric D-loop disassembly

DNA replication

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

DNA recombination

recombinational repair [inference]

double-strand break repair via homologous recombination

DNA-templated DNA replication maintenance of fidelity [inference]

replication fork processing

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cell cycle process [inference]

replicative senescence

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

cellular response to starvation

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance

telomeric loop disassembly [inference]

telomeric D-loop disassembly

DNA conformation change [inference]

DNA geometric change

cellular senescence

multicellular organismal process [inference]

determination of adult lifespan

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

cellular response to starvation

response to starvation [inference]

cellular response to starvation

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

response to UV-C

response to ionizing radiation [inference]

response to gamma radiation [inference]

cellular response to gamma radiation

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

response to starvation [inference]

cellular response to starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

recombinational repair [inference]

double-strand break repair via homologous recombination

double-strand break repair

double-strand break repair via homologous recombination

cellular response to starvation

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to ionizing radiation [inference]

cellular response to gamma radiation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein localization to nucleolus

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of growth rate

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of strand invasion

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of strand invasion

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of strand invasion

regulation of DNA metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of strand invasion

regulation of strand invasion [inference]

positive regulation of strand invasion

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of strand invasion

regulation of strand invasion [inference]

positive regulation of strand invasion

regulation of programmed cell death [inference]

regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of strand invasion

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity

Displaying entries **1 - 5** of 26 in total

1

2

3

4

5

6

Next ›

Last »
GO Term	Evidence Code	PMID
chromosome, telomeric region	ISO
chromosome, telomeric region	IMP
chromosome, telomeric region	IEA
nucleus	ISO
nucleus	EXP

GO Hierarchy

cellular component

cellular anatomical structure [inference]

microtubule organizing center [inference]

centrosome

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

chromosomal region [inference]

chromosome, telomeric region

supramolecular complex [inference]

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

Displaying entries **1 - 5** of 56 in total

1

2

3

4

5

…

Next ›

Last »
GO Term	Evidence Code	PMID
nucleotide binding	IEA
magnesium ion binding	ISS
magnesium ion binding	ISO
magnesium ion binding	IEA
four-way junction DNA binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

exonuclease activity

3'-5' exonuclease activity

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

helicase activity

DNA helicase activity

catalytic activity, acting on a nucleic acid [inference]

helicase activity

DNA helicase activity

nuclease activity [inference]

exonuclease activity

3'-5' exonuclease activity

catalytic activity, acting on DNA [inference]

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

binding [inference]

nucleic acid binding

DNA binding

DNA secondary structure binding [inference]

D-loop DNA binding [inference]

telomeric D-loop binding

damaged DNA binding [inference]

oxidized DNA binding [inference]

oxidized purine DNA binding [inference]

8-hydroxy-2'-deoxyguanosine DNA binding

sequence-specific DNA binding [inference]

telomeric repeat DNA binding [inference]

telomeric G-quadruplex DNA binding

G-quadruplex DNA binding

telomeric G-quadruplex DNA binding

flap-structured DNA binding [inference]

3'-flap-structured DNA binding

chromatin binding

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

transition metal ion binding [inference]

manganese ion binding

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding

mismatch repair complex binding [inference]

MutLalpha complex binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

helicase activity

DNA helicase activity

ATP-dependent activity, acting on DNA [inference]

DNA helicase activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:5688	Werner syndrome	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements