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NADPH oxidase 3

Summary

Gene Symbol

Nox3

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

224480

PubChem

224480

Alliance of Genome Resources

MGI:2681162

Annotation

Keyword

Cell membrane
Glycoprotein
Heme
Oxidoreductase
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q672J9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
temperature homeostasis	IMP	12434016
defense response	IBA
detection of gravity	IMP	10491954
response to gravity	IMP	12434016 15501603
superoxide anion generation	IBA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process [inference]

superoxide metabolic process [inference]

superoxide anion generation

multicellular organismal process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

developmental process [inference]

anatomical structure development [inference]

otolith development

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

temperature homeostasis

response to stimulus [inference]

response to stress [inference]

defense response

response to external stimulus [inference]

detection of external stimulus [inference]

detection of gravity

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of gravity

response to gravity

detection of gravity

detection of stimulus [inference]

detection of external stimulus [inference]

detection of gravity

detection of abiotic stimulus [inference]

detection of gravity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm	IDA	17140397
plasma membrane	IDA	17140397
plasma membrane	IBA
NADPH oxidase complex	IDA	17140397
NADPH oxidase complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

NADPH oxidase complex

catalytic complex [inference]

oxidoreductase complex [inference]

NADPH oxidase complex

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	17140397
superoxide-generating NAD(P)H oxidase activity	ISO
superoxide-generating NAD(P)H oxidase activity	IDA	17140397
superoxide-generating NAD(P)H oxidase activity	IMP	15326186
superoxide-generating NAD(P)H oxidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

superoxide-generating NAD(P)H oxidase activity

superoxide-generating NADPH oxidase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Respiratory burst

Functional Category

C: Energy production and conversion
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 6** entries
InterPro
FAD-binding 8
FAD-binding domain, ferredoxin reductase-type
Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Ferric reductase transmembrane component-like domain
Ferric reductase, NAD binding domain
Riboflavin synthase-like beta-barrel

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	13058	FB:FBgn0085428
Drosophila melanogaster	50490	FB:FBgn0085428
Homo sapiens	50508	HGNC:7890	HUMAN87145
Homo sapiens	224480	HGNC:7890
Drosophila melanogaster	237038	FB:FBgn0085428
Rattus norvegicus	292279	HGNC:7890	RATNO17350
Pan troglodytes	472169		PANTR39368
Canis lupus familiaris	484046		CANLF00231
Bos taurus	526999		BOVIN36026
Monodelphis domestica	100032293		MONDO11842