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ectonucleotide pyrophosphatase/phosphodiesterase 4

Summary

Gene Symbol

Enpp4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

224794

KEGG Gene ID

PubChem

224794

Alliance of Genome Resources

MGI:2682634

Annotation

Keyword

Alternative splicing
Blood coagulation
Cell membrane
Disulfide bond
Glycoprotein
Hydrolase
Metal-binding
Reference proteome
Signal
Transmembrane helix
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8BTJ4	AP3A hydrolase Ectonucleotide pyrophosphatase/phosphodiesterase family member 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
blood coagulation
positive regulation of blood coagulation	ISO
positive regulation of blood coagulation	IEA
purine ribonucleoside catabolic process	ISO
purine ribonucleoside catabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleobase-containing small molecule catabolic process [inference]

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

small molecule catabolic process [inference]

nucleobase-containing small molecule catabolic process [inference]

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine-containing compound catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleobase-containing small molecule catabolic process [inference]

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine ribonucleoside metabolic process [inference]

purine ribonucleoside catabolic process

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine nucleoside metabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine ribonucleoside metabolic process [inference]

purine ribonucleoside catabolic process

nucleobase-containing small molecule catabolic process [inference]

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

small molecule metabolic process [inference]

small molecule catabolic process [inference]

nucleobase-containing small molecule catabolic process [inference]

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine ribonucleoside metabolic process [inference]

purine ribonucleoside catabolic process

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine nucleoside metabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine ribonucleoside metabolic process [inference]

purine ribonucleoside catabolic process

nucleobase-containing small molecule catabolic process [inference]

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine-containing compound metabolic process [inference]

purine nucleoside metabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine ribonucleoside metabolic process [inference]

purine ribonucleoside catabolic process

purine-containing compound catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

carbohydrate derivative metabolic process [inference]

nucleoside metabolic process [inference]

ribonucleoside metabolic process [inference]

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine ribonucleoside metabolic process [inference]

purine ribonucleoside catabolic process

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine nucleoside metabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

purine ribonucleoside metabolic process [inference]

purine ribonucleoside catabolic process

carbohydrate derivative catabolic process [inference]

glycosyl compound catabolic process [inference]

nucleoside catabolic process [inference]

purine nucleoside catabolic process [inference]

purine ribonucleoside catabolic process

ribonucleoside catabolic process [inference]

purine ribonucleoside catabolic process

multicellular organismal process [inference]

coagulation [inference]

blood coagulation

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of response to stimulus [inference]

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of wound healing [inference]

positive regulation of blood coagulation

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of blood coagulation

regulation of multicellular organismal process [inference]

regulation of coagulation [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of coagulation [inference]

positive regulation of blood coagulation

positive regulation of multicellular organismal process [inference]

positive regulation of coagulation [inference]

positive regulation of blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

regulation of biological quality [inference]

regulation of body fluid levels [inference]

hemostasis [inference]

blood coagulation

regulation of hemostasis [inference]

regulation of blood coagulation [inference]

positive regulation of blood coagulation

positive regulation of hemostasis [inference]

positive regulation of blood coagulation

Displaying 1 entry
GO Term	Evidence Code	PMID
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
metal ion binding
bis(5'-adenosyl)-triphosphatase activity	ISO
bis(5'-adenosyl)-triphosphatase activity	IBA
bis(5'-adenosyl)-triphosphatase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

bis(5'-adenosyl)-triphosphatase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Rhea

RHEA:13893

H₂O + P¹,P³-bis(5'-adenosyl) triphosphate

H⁺ + AMP + ADP

Enzyme

3.6.1.29

PMID

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	22875	HGNC:3359
Saccharomyces cerevisiae S288C	850391	SGD:S000000621
Saccharomyces cerevisiae S288C	856699	SGD:S000000742
Danio rerio	550586	ZFIN:ZDB-GENE-050417-444
Xenopus tropicalis	550082	Xenbase:XB-GENE-1013025
Caenorhabditis elegans	177430	WB:WBGene00015283